Neuroplastin in Neuropsychiatric Diseases
Molecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are insufficiently elucidated. A detailed understanding of these mechanisms may help to further improve medical intervention. Recently, intellectual abilities, creativity, and amnesia have been associated with neuroplast...
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Format: | Article |
Language: | English |
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MDPI AG
2021-09-01
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Series: | Genes |
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Online Access: | https://www.mdpi.com/2073-4425/12/10/1507 |
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author | Xiao Lin Yi Liang Rodrigo Herrera-Molina Dirk Montag |
author_facet | Xiao Lin Yi Liang Rodrigo Herrera-Molina Dirk Montag |
author_sort | Xiao Lin |
collection | DOAJ |
description | Molecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are insufficiently elucidated. A detailed understanding of these mechanisms may help to further improve medical intervention. Recently, intellectual abilities, creativity, and amnesia have been associated with neuroplastin, a cell recognition glycoprotein of the immunoglobulin superfamily that participates in synapse formation and function and calcium signaling. Data from animal models suggest a role for neuroplastin in pathways affected in neuropsychiatric and neurodegenerative diseases. Neuroplastin loss or disruption of molecular pathways related to neuronal processes has been linked to various neurological diseases, including dementia, schizophrenia, and Alzheimer’s disease. Here, we review the molecular features of the cell recognition molecule neuroplastin, and its binding partners, which are related to neurological processes and involved in learning and memory. The emerging functions of neuroplastin may have implications for the treatment of diseases, particularly those of the nervous system. |
first_indexed | 2024-03-10T06:33:09Z |
format | Article |
id | doaj.art-d25216e8b50f4db289e2601ed370a55a |
institution | Directory Open Access Journal |
issn | 2073-4425 |
language | English |
last_indexed | 2024-03-10T06:33:09Z |
publishDate | 2021-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Genes |
spelling | doaj.art-d25216e8b50f4db289e2601ed370a55a2023-11-22T18:21:00ZengMDPI AGGenes2073-44252021-09-011210150710.3390/genes12101507Neuroplastin in Neuropsychiatric DiseasesXiao Lin0Yi Liang1Rodrigo Herrera-Molina2Dirk Montag3Neurogenetics Laboratory, Leibniz Institute for Neurobiology, Brenneckestr. 6, D-39118 Magdeburg, GermanyNeurogenetics Laboratory, Leibniz Institute for Neurobiology, Brenneckestr. 6, D-39118 Magdeburg, GermanyCombinatorial NeuroImaging (CNI), Leibniz Institute for Neurobiology, Brenneckestr. 6, D-39118 Magdeburg, GermanyNeurogenetics Laboratory, Leibniz Institute for Neurobiology, Brenneckestr. 6, D-39118 Magdeburg, GermanyMolecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are insufficiently elucidated. A detailed understanding of these mechanisms may help to further improve medical intervention. Recently, intellectual abilities, creativity, and amnesia have been associated with neuroplastin, a cell recognition glycoprotein of the immunoglobulin superfamily that participates in synapse formation and function and calcium signaling. Data from animal models suggest a role for neuroplastin in pathways affected in neuropsychiatric and neurodegenerative diseases. Neuroplastin loss or disruption of molecular pathways related to neuronal processes has been linked to various neurological diseases, including dementia, schizophrenia, and Alzheimer’s disease. Here, we review the molecular features of the cell recognition molecule neuroplastin, and its binding partners, which are related to neurological processes and involved in learning and memory. The emerging functions of neuroplastin may have implications for the treatment of diseases, particularly those of the nervous system.https://www.mdpi.com/2073-4425/12/10/1507plasma membrane calcium ATPasePMCAautismschizophreniaAlzheimer’s diseasecalcium homeostasis |
spellingShingle | Xiao Lin Yi Liang Rodrigo Herrera-Molina Dirk Montag Neuroplastin in Neuropsychiatric Diseases Genes plasma membrane calcium ATPase PMCA autism schizophrenia Alzheimer’s disease calcium homeostasis |
title | Neuroplastin in Neuropsychiatric Diseases |
title_full | Neuroplastin in Neuropsychiatric Diseases |
title_fullStr | Neuroplastin in Neuropsychiatric Diseases |
title_full_unstemmed | Neuroplastin in Neuropsychiatric Diseases |
title_short | Neuroplastin in Neuropsychiatric Diseases |
title_sort | neuroplastin in neuropsychiatric diseases |
topic | plasma membrane calcium ATPase PMCA autism schizophrenia Alzheimer’s disease calcium homeostasis |
url | https://www.mdpi.com/2073-4425/12/10/1507 |
work_keys_str_mv | AT xiaolin neuroplastininneuropsychiatricdiseases AT yiliang neuroplastininneuropsychiatricdiseases AT rodrigoherreramolina neuroplastininneuropsychiatricdiseases AT dirkmontag neuroplastininneuropsychiatricdiseases |