Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor
The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date. Here, the authors combine NMR and ESR spectroscopy to determine the full-length ICD structures of the human α7 nicotinic acetylcholine rec...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28400-x |
| _version_ | 1818977069906788352 |
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| author | Vasyl Bondarenko Marta M. Wells Qiang Chen Tommy S. Tillman Kevin Singewald Matthew J. Lawless Joel Caporoso Nicole Brandon Jonathan A. Coleman Sunil Saxena Erik Lindahl Yan Xu Pei Tang |
| author_facet | Vasyl Bondarenko Marta M. Wells Qiang Chen Tommy S. Tillman Kevin Singewald Matthew J. Lawless Joel Caporoso Nicole Brandon Jonathan A. Coleman Sunil Saxena Erik Lindahl Yan Xu Pei Tang |
| author_sort | Vasyl Bondarenko |
| collection | DOAJ |
| description | The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date. Here, the authors combine NMR and ESR spectroscopy to determine the full-length ICD structures of the human α7 nicotinic acetylcholine receptor (α7nAChR). |
| first_indexed | 2024-12-20T16:21:53Z |
| format | Article |
| id | doaj.art-d2525994f44840ae925d4fd374218a26 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:21:53Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d2525994f44840ae925d4fd374218a262022-12-21T19:33:36ZengNature PortfolioNature Communications2041-17232022-02-011311910.1038/s41467-022-28400-xStructures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptorVasyl Bondarenko0Marta M. Wells1Qiang Chen2Tommy S. Tillman3Kevin Singewald4Matthew J. Lawless5Joel Caporoso6Nicole Brandon7Jonathan A. Coleman8Sunil Saxena9Erik Lindahl10Yan Xu11Pei Tang12Depatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepartment of Chemistry, University of PittsburghDepartment of Chemistry, University of PittsburghDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepartment of Structural Biology, University of PittsburghDepartment of Chemistry, University of PittsburghDepartment of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm UniversityDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghDepatment of Anesthesiology and Perioperative Medicine, University of PittsburghThe intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date. Here, the authors combine NMR and ESR spectroscopy to determine the full-length ICD structures of the human α7 nicotinic acetylcholine receptor (α7nAChR).https://doi.org/10.1038/s41467-022-28400-x |
| spellingShingle | Vasyl Bondarenko Marta M. Wells Qiang Chen Tommy S. Tillman Kevin Singewald Matthew J. Lawless Joel Caporoso Nicole Brandon Jonathan A. Coleman Sunil Saxena Erik Lindahl Yan Xu Pei Tang Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor Nature Communications |
| title | Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor |
| title_full | Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor |
| title_fullStr | Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor |
| title_full_unstemmed | Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor |
| title_short | Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor |
| title_sort | structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor |
| url | https://doi.org/10.1038/s41467-022-28400-x |
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