Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer
Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/1/12 |
| _version_ | 1797342829164363776 |
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| author | Ana Luísa De Sousa-Coelho Gil Fraqueza Manuel Aureliano |
| author_facet | Ana Luísa De Sousa-Coelho Gil Fraqueza Manuel Aureliano |
| author_sort | Ana Luísa De Sousa-Coelho |
| collection | DOAJ |
| description | Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs, potentially improving their efficacy in cancer treatment. In this review, covering the last 25 years of research in the field, we identified non-oncology-approved drugs suitable as ligands to obtain different vanadium complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs, and cetirizine and imidazole-based oxidovanadium(IV) complexes, each has a parent drug known to have different medicinal properties and therapeutic indications, and all showed potential as novel anticancer treatments. Nevertheless, the precise mechanisms of action for these vanadium compounds against cancer are still not fully understood. |
| first_indexed | 2024-03-08T10:38:51Z |
| format | Article |
| id | doaj.art-d2526b6807fa4544abb55449f6068acb |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-08T10:38:51Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d2526b6807fa4544abb55449f6068acb2024-01-26T18:04:40ZengMDPI AGPharmaceuticals1424-82472023-12-011711210.3390/ph17010012Repurposing Therapeutic Drugs Complexed to Vanadium in CancerAna Luísa De Sousa-Coelho0Gil Fraqueza1Manuel Aureliano2Algarve Biomedical Center Research Institute (ABC-RI), Universidade do Algarve, 8005-139 Faro, PortugalInstituto Superior de Engenharia (ISE), Universidade do Algarve, 8005-139 Faro, PortugalCentro de Ciências do Mar (CCMar), Universidade do Algarve, 8005-139 Faro, PortugalRepurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs, potentially improving their efficacy in cancer treatment. In this review, covering the last 25 years of research in the field, we identified non-oncology-approved drugs suitable as ligands to obtain different vanadium complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs, and cetirizine and imidazole-based oxidovanadium(IV) complexes, each has a parent drug known to have different medicinal properties and therapeutic indications, and all showed potential as novel anticancer treatments. Nevertheless, the precise mechanisms of action for these vanadium compounds against cancer are still not fully understood.https://www.mdpi.com/1424-8247/17/1/12drug repurposingvanadium complexesvanadatedecavanadatecancer treatment |
| spellingShingle | Ana Luísa De Sousa-Coelho Gil Fraqueza Manuel Aureliano Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer Pharmaceuticals drug repurposing vanadium complexes vanadate decavanadate cancer treatment |
| title | Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer |
| title_full | Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer |
| title_fullStr | Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer |
| title_full_unstemmed | Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer |
| title_short | Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer |
| title_sort | repurposing therapeutic drugs complexed to vanadium in cancer |
| topic | drug repurposing vanadium complexes vanadate decavanadate cancer treatment |
| url | https://www.mdpi.com/1424-8247/17/1/12 |
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