Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis
ObjectivesThis study was designed to evaluate the clinical, histological and immunohistochemical findings and treatment of chronic actinic dermatitis in Korean patients. MethodsSeventeen Korean patients with chronic actinic dermatitis were enrolled for this study. The clinical and histological findi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kosin University College of Medicine
2013-12-01
|
| Series: | Kosin Medical Journal |
| Subjects: | |
| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc028-02-09.pdf |
| _version_ | 1797991516140994560 |
|---|---|
| author | Min Soo Jang Kang Hoon Lee Sang Hwa Han Jong Bin Park Dong Young Kang Sang Tae Kim Kee Suck Suh |
| author_facet | Min Soo Jang Kang Hoon Lee Sang Hwa Han Jong Bin Park Dong Young Kang Sang Tae Kim Kee Suck Suh |
| author_sort | Min Soo Jang |
| collection | DOAJ |
| description | ObjectivesThis study was designed to evaluate the clinical, histological and immunohistochemical findings and treatment of chronic actinic dermatitis in Korean patients. MethodsSeventeen Korean patients with chronic actinic dermatitis were enrolled for this study. The clinical and histological findings and the results of phototest were reviewed with medical records, clinical photographs and pathologic slides. We also reviewed the effectiveness of the treatments in all patients with chronic actinic dermatitis. ResultsIn all patients with chronic actinic dermatitis, pruritus was severe, and the patients present in the early stages with erythemas on the face, neck and the back of the hands. As the eruption progresses, it became lichenified and scaly plaques and papules developed. The face, upper extremity and neck were most commonly affected. The most common abnormal results of the phototests were decreased MED-UVB alone. In 8 patients with actinic reticuloid, histopathologic findings showed irregular acanthosis, parakeratosis, spongiosis, atypical hyperchromatic cells with cerebriform nuclei, epidermotropism, Pautrier-like microabscess, deep perivascular lymphocytic infiltrates, vertically-streaked collagen in the papillary dermis, stellate and multinucleated fibroblasts. Treatment includes topical tacrolimus and corticosteroid, oral corticosteroid, azathioprine and cyclosporine. ConclusionsOur study showed classic clinical and histological findings. The most common abnormal results of the phototests were decreased MED-UVB alone. Topical steroid, tacrolimus and systemic cyclosporine, azathioprine are effective in treating chronic actinic dermatitis. |
| first_indexed | 2024-04-11T08:53:18Z |
| format | Article |
| id | doaj.art-d254ab3c073247d5a53cbe717e120281 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T08:53:18Z |
| publishDate | 2013-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-d254ab3c073247d5a53cbe717e1202812022-12-22T04:33:25ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242013-12-0128214515310.7180/kmj.2013.28.2.145118Clinical Features and Histological Findings of 17 Patients with Chronic Actinic DermatitisMin Soo Jang0Kang Hoon Lee1Sang Hwa Han2Jong Bin Park3Dong Young Kang4Sang Tae Kim5Kee Suck SuhDepartment of Dermatology, College of Medicine, Kosin University, Busan, KoreaDepartment of Dermatology, College of Medicine, Kosin University, Busan, KoreaDepartment of Dermatology, College of Medicine, Kosin University, Busan, KoreaDepartment of Dermatology, College of Medicine, Kosin University, Busan, KoreaDepartment of Dermatology, College of Medicine, Kosin University, Busan, KoreaDepartment of Dermatology, College of Medicine, Kosin University, Busan, KoreaObjectivesThis study was designed to evaluate the clinical, histological and immunohistochemical findings and treatment of chronic actinic dermatitis in Korean patients. MethodsSeventeen Korean patients with chronic actinic dermatitis were enrolled for this study. The clinical and histological findings and the results of phototest were reviewed with medical records, clinical photographs and pathologic slides. We also reviewed the effectiveness of the treatments in all patients with chronic actinic dermatitis. ResultsIn all patients with chronic actinic dermatitis, pruritus was severe, and the patients present in the early stages with erythemas on the face, neck and the back of the hands. As the eruption progresses, it became lichenified and scaly plaques and papules developed. The face, upper extremity and neck were most commonly affected. The most common abnormal results of the phototests were decreased MED-UVB alone. In 8 patients with actinic reticuloid, histopathologic findings showed irregular acanthosis, parakeratosis, spongiosis, atypical hyperchromatic cells with cerebriform nuclei, epidermotropism, Pautrier-like microabscess, deep perivascular lymphocytic infiltrates, vertically-streaked collagen in the papillary dermis, stellate and multinucleated fibroblasts. Treatment includes topical tacrolimus and corticosteroid, oral corticosteroid, azathioprine and cyclosporine. ConclusionsOur study showed classic clinical and histological findings. The most common abnormal results of the phototests were decreased MED-UVB alone. Topical steroid, tacrolimus and systemic cyclosporine, azathioprine are effective in treating chronic actinic dermatitis.http://www.kosinmedj.org/upload/pdf/ksmc028-02-09.pdfchronic actinic dermatitisclinical featureshistological findings |
| spellingShingle | Min Soo Jang Kang Hoon Lee Sang Hwa Han Jong Bin Park Dong Young Kang Sang Tae Kim Kee Suck Suh Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis Kosin Medical Journal chronic actinic dermatitis clinical features histological findings |
| title | Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis |
| title_full | Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis |
| title_fullStr | Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis |
| title_full_unstemmed | Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis |
| title_short | Clinical Features and Histological Findings of 17 Patients with Chronic Actinic Dermatitis |
| title_sort | clinical features and histological findings of 17 patients with chronic actinic dermatitis |
| topic | chronic actinic dermatitis clinical features histological findings |
| url | http://www.kosinmedj.org/upload/pdf/ksmc028-02-09.pdf |
| work_keys_str_mv | AT minsoojang clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis AT kanghoonlee clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis AT sanghwahan clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis AT jongbinpark clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis AT dongyoungkang clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis AT sangtaekim clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis AT keesucksuh clinicalfeaturesandhistologicalfindingsof17patientswithchronicactinicdermatitis |