Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension
Background: As a complication of pregnancy, uncontrolled hypertension will continue to be a complication that harms both mother and baby. Pomegranate peel, which contains high antioxidants, is potentially used as an antihypertensive of adjuvant pharmacological therapy. However, there has been no res...
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| Format: | Article |
| Language: | English |
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Universitas Muhammadiyah Purwokerto
2023-08-01
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| Series: | Medisains |
| Subjects: | |
| Online Access: | https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/17484 |
| _version_ | 1797692623524200448 |
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| author | Farah Salsabila Suharyo Hadisaputro Lanny Sunarjo |
| author_facet | Farah Salsabila Suharyo Hadisaputro Lanny Sunarjo |
| author_sort | Farah Salsabila |
| collection | DOAJ |
| description | Background: As a complication of pregnancy, uncontrolled hypertension will continue to be a complication that harms both mother and baby. Pomegranate peel, which contains high antioxidants, is potentially used as an antihypertensive of adjuvant pharmacological therapy. However, there has been no research on the effect of pomegranate extract in lowering blood pressure, so it is necessary to do related research.
Purpose: Analyze the effect of pomegranate peel extract on blood pressure and nitric oxide levels in gestational hypertension.
Methods: This is a quasi-experiment design pre-post-test with the control group. Through purposive sampling techniques, 32 respondents were divided into two groups. During 14 days, the intervention group received nifedipine 10 mg/day with 500 mg of pomegranate peel extract, while another group was only given nifedipine 10 mg/day.
Results: The blood pressure of the intervention group decreased compared to the control group (p<0.05). Meanwhile, the nitric oxide level of the intervention group is increased compared to the control group (p<0.05).
Conclusions: Pomegranate peel extract can reduce blood pressure and enhance nitric oxide levels in gestational hypertension. |
| first_indexed | 2024-03-12T02:31:17Z |
| format | Article |
| id | doaj.art-d2557b6e45434d56afe6687f876c27a8 |
| institution | Directory Open Access Journal |
| issn | 1693-7309 2621-2366 |
| language | English |
| last_indexed | 2024-03-12T02:31:17Z |
| publishDate | 2023-08-01 |
| publisher | Universitas Muhammadiyah Purwokerto |
| record_format | Article |
| series | Medisains |
| spelling | doaj.art-d2557b6e45434d56afe6687f876c27a82023-09-05T08:05:16ZengUniversitas Muhammadiyah PurwokertoMedisains1693-73092621-23662023-08-01212414510.30595/medisains.v21i2.174845463Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertensionFarah Salsabila0Suharyo Hadisaputro1Lanny Sunarjo2Poltekkes Kemenkes Semarang<em>Postgraduate Program in Applied Health, Poltekkes Kemenkes Semarang, Central Java, Indonesia</em><p><em>Postgraduate Program in Applied Health, Poltekkes Kemenkes Semarang, Central Java, Indonesia</em></p>Background: As a complication of pregnancy, uncontrolled hypertension will continue to be a complication that harms both mother and baby. Pomegranate peel, which contains high antioxidants, is potentially used as an antihypertensive of adjuvant pharmacological therapy. However, there has been no research on the effect of pomegranate extract in lowering blood pressure, so it is necessary to do related research. Purpose: Analyze the effect of pomegranate peel extract on blood pressure and nitric oxide levels in gestational hypertension. Methods: This is a quasi-experiment design pre-post-test with the control group. Through purposive sampling techniques, 32 respondents were divided into two groups. During 14 days, the intervention group received nifedipine 10 mg/day with 500 mg of pomegranate peel extract, while another group was only given nifedipine 10 mg/day. Results: The blood pressure of the intervention group decreased compared to the control group (p<0.05). Meanwhile, the nitric oxide level of the intervention group is increased compared to the control group (p<0.05). Conclusions: Pomegranate peel extract can reduce blood pressure and enhance nitric oxide levels in gestational hypertension.https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/17484pomegranateantihypertensive agentsnitric oxidehypertension pregnancy-induced |
| spellingShingle | Farah Salsabila Suharyo Hadisaputro Lanny Sunarjo Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension Medisains pomegranate antihypertensive agents nitric oxide hypertension pregnancy-induced |
| title | Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension |
| title_full | Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension |
| title_fullStr | Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension |
| title_full_unstemmed | Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension |
| title_short | Effect of pomegranate extract (Punica granatum L.) on blood pressure and nitric oxide in gestational hypertension |
| title_sort | effect of pomegranate extract punica granatum l on blood pressure and nitric oxide in gestational hypertension |
| topic | pomegranate antihypertensive agents nitric oxide hypertension pregnancy-induced |
| url | https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/17484 |
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