TRPC3 Regulates Islet Beta‐Cell Insulin Secretion

TRPC3 Regulates Islet Beta‐Cell Insulin Secretion

Abstract Insulin release is tightly controlled by glucose‐stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non‐selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose‐stimulated ins...

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Bibliographic Details
Main Authors: Gaëlle Rached, Youakim Saliba, Dina Maddah, Joelle Hajal, Viviane Smayra, Jules‐Joel Bakhos, Klaus Groschner, Lutz Birnbaumer, Nassim Fares
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Advanced Science
Subjects:
beta cells
calcium
diabetes
insulin
TRPC3
Online Access:https://doi.org/10.1002/advs.202204846

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