The role of selenium on autophagy
Selenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth retardation. Its antioxidant properties are integrated i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine
2022-12-01
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| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/18669 |
| _version_ | 1827906305808924672 |
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| author | Febriana Kurniasari Hanna Goenawan Astrid Feinisa Khairani Sunarjati Sudigdo Adi Ronny Lesmana Setiawan |
| author_facet | Febriana Kurniasari Hanna Goenawan Astrid Feinisa Khairani Sunarjati Sudigdo Adi Ronny Lesmana Setiawan |
| author_sort | Febriana Kurniasari |
| collection | DOAJ |
| description | Selenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth retardation. Its antioxidant properties are integrated into various selenoenzymes, mainly glutathione peroxidase (GPx) and thioredoxin reductase (Trx). These selenoenzymes act as a protective mechanism to prevent oxidative stress-induced cellular injury, regulate DNA transcription, and cell proliferation. Decreased levels of antioxidants induce reactive oxygen species (ROS) accumulation resulting in loss of mitochondrial structure and function. The antioxidant properties of selenium could depress ROS and modulates autophagy by interfering initiation of autophagy and phagophore formation. Inhibition at the initiation stage not only involves mTOR and AMPK, an autophagy-related regulators, but also autophagy markers, including Beclin 1, Atg5, LC3, and p62; thus, phagophore and autophagosome are not formed. This review will discuss the role of selenium in modulating autophagy in various organs. |
| first_indexed | 2024-03-13T00:54:36Z |
| format | Article |
| id | doaj.art-d259603565f7427287e353a2ef91f3b1 |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-03-13T00:54:36Z |
| publishDate | 2022-12-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-d259603565f7427287e353a2ef91f3b12023-07-07T07:41:35ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502022-12-0130030710.20885/JKKI.Vol13.Iss3.art1014835The role of selenium on autophagyFebriana Kurniasari0https://orcid.org/0000-0001-5882-0181Hanna Goenawan1Astrid Feinisa Khairani2Sunarjati Sudigdo Adi3Ronny Lesmana4Setiawan5Graduate Programme of Antiaging and Aesthetic Medicine, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaDivision of Physiology, Departement of Biomedical Science, Faculty of Medicine Universitas Padjajaran, Bandung, IndonesiaA)Graduate Programme of Antiaging and Aesthetic Medicine, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia , B)Division of Biological Activity, Central Laboratory, Universitas Padjajaran, Bandung, IndonesiaDivision of Cell Biology Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaA)Graduate Programme of Antiaging and Aesthetic Medicine, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia , B)Division of Physiology, Departement of Biomedical Science, Faculty of Medicine Universitas Padjajaran, Bandung, IndonesiaDivision of Physiology, Departement of Biomedical Science, Faculty of Medicine Universitas Padjajaran, Bandung, IndonesiaSelenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth retardation. Its antioxidant properties are integrated into various selenoenzymes, mainly glutathione peroxidase (GPx) and thioredoxin reductase (Trx). These selenoenzymes act as a protective mechanism to prevent oxidative stress-induced cellular injury, regulate DNA transcription, and cell proliferation. Decreased levels of antioxidants induce reactive oxygen species (ROS) accumulation resulting in loss of mitochondrial structure and function. The antioxidant properties of selenium could depress ROS and modulates autophagy by interfering initiation of autophagy and phagophore formation. Inhibition at the initiation stage not only involves mTOR and AMPK, an autophagy-related regulators, but also autophagy markers, including Beclin 1, Atg5, LC3, and p62; thus, phagophore and autophagosome are not formed. This review will discuss the role of selenium in modulating autophagy in various organs.https://journal.uii.ac.id/JKKI/article/view/18669 |
| spellingShingle | Febriana Kurniasari Hanna Goenawan Astrid Feinisa Khairani Sunarjati Sudigdo Adi Ronny Lesmana Setiawan The role of selenium on autophagy JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| title | The role of selenium on autophagy |
| title_full | The role of selenium on autophagy |
| title_fullStr | The role of selenium on autophagy |
| title_full_unstemmed | The role of selenium on autophagy |
| title_short | The role of selenium on autophagy |
| title_sort | role of selenium on autophagy |
| url | https://journal.uii.ac.id/JKKI/article/view/18669 |
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