Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs

Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs

Endothelial progenitor cells (EPCs) are reduced in number and impaired in function in diabetic patients. Whether and how Nrf2 regulates the function of diabetic EPCs remains unclear. In this study, we found that the expression of Nrf2 and its downstream genes were decreased in EPCs from both diabeti...

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Bibliographic Details
Main Authors:	Xiaozhen Dai, Kai Wang, Jiawei Fan, Hanjie Liu, Xia Fan, Qian Lin, Yuhang Chen, Hu Chen, Yao Li, Hairong Liu, Oscar Chen, Jing Chen, Xiaohong Li, Di Ren, Ji Li, Daniel J. Conklin, Kupper A. Wintergerst, Yu Li, Lu Cai, Zhongbin Deng, Xiaoqing Yan, Yi Tan
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Series:	Redox Biology
Subjects:	Endothelial progenitor cell Nuclear factor erythroid 2-related factor 2 Angiogenesis Hind limb ischemia Diabetes
Online Access:	http://www.sciencedirect.com/science/article/pii/S221323172200221X

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