Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator
Ke Song,1 Yiran Hu,1,2 Wei Chen,1 Wei Hua,2 Zening Jin1 1Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Aca...
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Dove Medical Press
2022-04-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/prediction-efficiency-of-madit-icd-benefit-score-for-outcome-in-asian--peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818115825835442176 |
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| author | Song K Hu Y Chen W Hua W Jin Z |
| author_facet | Song K Hu Y Chen W Hua W Jin Z |
| author_sort | Song K |
| collection | DOAJ |
| description | Ke Song,1 Yiran Hu,1,2 Wei Chen,1 Wei Hua,2 Zening Jin1 1Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Zening Jin, Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, 100070, People’s Republic of China, Email zening_jin@126.com Wei Hua, Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, North Lishi Road No.167, Beijing, 100073, People’s Republic of China, Tel +86 010-59975832, Email drhuaweifw@sina.comBackground: Not all patients with heart failure derive consistent benefit from prophylactic implantable cardioverter-defibrillator (ICD). We aimed to evaluate the role of MADIT-ICD benefit score in risk-stratifying in Asian patients with left ventricular ejection fraction (LVEF) ≤ 35%.Methods: In this two-center, retrospective study, a total of 136 patients with LVEF ≤ 35% who received an ICD for primary prevention were enrolled. The endpoints were defined as the ventricular tachycardia ≥ 200bpm (VT) or ventricular fibrillation (VF) and non-arrhythmic death. Based on the MADIT-ICD benefit score system, all patients were categorized into three groups: highest benefit group (n = 41), intermediate benefit group (n = 80), and lowest benefit group (n = 15).Results: Forty patients experienced VT/VF and seven died of non-arrhythmic causes during a median follow-up of 44.8 ± 28.9 months. Kaplan–Meier curves showed that patients in highest benefit group had a worse VT/VF occurrence compared to those in other groups. In the highest benefit group, the predicted risk of VT/VF was 17-fold higher than the risk of non-arrhythmic mortality (41.5% vs 2.4%, P < 0.001). In the intermediate benefit group, the predicted risk of VT/VF was 4.2-fold higher than the risk of non-arrhythmic mortality (26.3% vs 6.3%, P = 0.001). In the lowest benefit group, however, the difference in the corresponding predicted risks was attenuated without statistically significant (13.3% vs 5.1%, P = 0.56).Conclusion: We demonstrate that MADIT-ICD benefit score can be used for the assessment of ICD primary prevention benefits in Asian patients with LVEF ≤ 35%.Keywords: implantable cardioverter-defibrillator, primary prevention, risk score, risk stratification, heart failure with reduced ejection fraction |
| first_indexed | 2024-12-11T04:12:47Z |
| format | Article |
| id | doaj.art-d25c9463886241b2857c82ee787ed0bc |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-11T04:12:47Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-d25c9463886241b2857c82ee787ed0bc2022-12-22T01:21:20ZengDove Medical PressInternational Journal of General Medicine1178-70742022-04-01Volume 154409441674821Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-DefibrillatorSong KHu YChen WHua WJin ZKe Song,1 Yiran Hu,1,2 Wei Chen,1 Wei Hua,2 Zening Jin1 1Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Zening Jin, Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing, 100070, People’s Republic of China, Email zening_jin@126.com Wei Hua, Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, North Lishi Road No.167, Beijing, 100073, People’s Republic of China, Tel +86 010-59975832, Email drhuaweifw@sina.comBackground: Not all patients with heart failure derive consistent benefit from prophylactic implantable cardioverter-defibrillator (ICD). We aimed to evaluate the role of MADIT-ICD benefit score in risk-stratifying in Asian patients with left ventricular ejection fraction (LVEF) ≤ 35%.Methods: In this two-center, retrospective study, a total of 136 patients with LVEF ≤ 35% who received an ICD for primary prevention were enrolled. The endpoints were defined as the ventricular tachycardia ≥ 200bpm (VT) or ventricular fibrillation (VF) and non-arrhythmic death. Based on the MADIT-ICD benefit score system, all patients were categorized into three groups: highest benefit group (n = 41), intermediate benefit group (n = 80), and lowest benefit group (n = 15).Results: Forty patients experienced VT/VF and seven died of non-arrhythmic causes during a median follow-up of 44.8 ± 28.9 months. Kaplan–Meier curves showed that patients in highest benefit group had a worse VT/VF occurrence compared to those in other groups. In the highest benefit group, the predicted risk of VT/VF was 17-fold higher than the risk of non-arrhythmic mortality (41.5% vs 2.4%, P < 0.001). In the intermediate benefit group, the predicted risk of VT/VF was 4.2-fold higher than the risk of non-arrhythmic mortality (26.3% vs 6.3%, P = 0.001). In the lowest benefit group, however, the difference in the corresponding predicted risks was attenuated without statistically significant (13.3% vs 5.1%, P = 0.56).Conclusion: We demonstrate that MADIT-ICD benefit score can be used for the assessment of ICD primary prevention benefits in Asian patients with LVEF ≤ 35%.Keywords: implantable cardioverter-defibrillator, primary prevention, risk score, risk stratification, heart failure with reduced ejection fractionhttps://www.dovepress.com/prediction-efficiency-of-madit-icd-benefit-score-for-outcome-in-asian--peer-reviewed-fulltext-article-IJGMimplantable cardioverter-defibrillatorprimary preventionrisk scorerisk stratificationheart failure with reduced ejection fraction. |
| spellingShingle | Song K Hu Y Chen W Hua W Jin Z Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator International Journal of General Medicine implantable cardioverter-defibrillator primary prevention risk score risk stratification heart failure with reduced ejection fraction. |
| title | Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator |
| title_full | Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator |
| title_fullStr | Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator |
| title_full_unstemmed | Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator |
| title_short | Prediction Efficiency of MADIT-ICD Benefit Score for Outcome in Asian Patients with Implantable Cardioverter-Defibrillator |
| title_sort | prediction efficiency of madit icd benefit score for outcome in asian patients with implantable cardioverter defibrillator |
| topic | implantable cardioverter-defibrillator primary prevention risk score risk stratification heart failure with reduced ejection fraction. |
| url | https://www.dovepress.com/prediction-efficiency-of-madit-icd-benefit-score-for-outcome-in-asian--peer-reviewed-fulltext-article-IJGM |
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