Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease

Weakly activated core neuroinflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease

ObjectivesNeuroinflammation signaling has been identified as an important hallmark of Alzheimer’s disease (AD) in addition to amyloid β plaques (Aβ) and neurofibrillary tangles (NFTs). However, the molecular mechanisms and biological processes of neuroinflammation remain unclear and have not well de...

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Bibliographic Details
Main Authors: Fuhai Li, Abdallah M. Eteleeb, William Buchser, Christopher Sohn, Guoqiao Wang, Chengjie Xiong, Philip R. Payne, Eric McDade, Celeste M. Karch, Oscar Harari, Carlos Cruchaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
neuroinflammation
signaling network
Alzheimer’s disease
molecular mechanism
signaling targets
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.935279/full

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