Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis
Introduction: Hyperhidrosis is excessive sweating beyond thermoregulatory needs. It is a potentially disabling condition with challenging management. Aluminum chloride is the established topical treatment; however, response remains unsatisfactory. Oxybutynin is an anticholinergic drug that stands a...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2023-07-01
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| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | http://dpcj.org/index.php/dpc/article/view/3067 |
| _version_ | 1797756398490091520 |
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| author | Amany El-Agamy El-Samadony Doaa Salah Hegab Gamal Mohamed El Maghraby Iman Hamed El-Maadawy |
| author_facet | Amany El-Agamy El-Samadony Doaa Salah Hegab Gamal Mohamed El Maghraby Iman Hamed El-Maadawy |
| author_sort | Amany El-Agamy El-Samadony |
| collection | DOAJ |
| description |
Introduction: Hyperhidrosis is excessive sweating beyond thermoregulatory needs. It is a potentially disabling condition with challenging management. Aluminum chloride is the established topical treatment; however, response remains unsatisfactory. Oxybutynin is an anticholinergic drug that stands as a therapeutic chance for hyperhidrosis.
Objectives: comparing the efficacy of topical oxybutynin 3% gel versus aluminum chloride 15% lotion in treatment of primary focal hyperhidrosis.
Methods: Forty patients with hyperhidrosis were randomly distributed into 2 equal groups treated by either topical oxybutynin 3% gel or topical aluminum chloride 15% lotion once daily night application for 4 weeks (both groups). Evaluation was done at 2 and 4 weeks of treatment and after 1 month of the end of treatment for follow up by Minor iodine starch test, hyperhidrosis disease severity scale (HDSS) and dermatology life quality index (DLQI).
Results: Both treatment modalities were effective with insignificant differences between patients of both groups regarding improvement in Minor iodine starch test and HDSS after 2 weeks of treatment (P = 0.561, 0.33 respectively). Oxybutynin 3% gel yielded significantly better improvement of Minor’s test, HDSS and patient’s quality of life at the end of 4 weeks of treatment with lower recurrence rate than aluminum chloride 15% lotion at 1 month follow up. Minimal adverse effects were noted in both studied groups.
Conclusions: Oxybutynin 3% gel could be considered as a promising treatment modality for hyperhidrosis with higher efficacy than aluminum chloride 15% lotion and lower recurrence rate.
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| first_indexed | 2024-03-12T18:00:48Z |
| format | Article |
| id | doaj.art-d25dfa5765d343b4afa893ee0d1e9ac4 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-03-12T18:00:48Z |
| publishDate | 2023-07-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-d25dfa5765d343b4afa893ee0d1e9ac42023-08-02T12:23:38ZengMattioli1885Dermatology Practical & Conceptual2160-93812023-07-0113310.5826/dpc.1303a192Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal HyperhidrosisAmany El-Agamy El-Samadony0Doaa Salah Hegab1Gamal Mohamed El Maghraby2Iman Hamed El-Maadawy3Faculty of Medicine, Dermatology and Venereology Department, Tanta University, Tanta, EgyptFaculty of Medicine, Dermatology and Venereology Department, Tanta University, Tanta, EgyptFaculty of Pharmacy, Pharmaceutical Technology Department, Tanta University, Tanta, EgyptFaculty of Medicine, Dermatology and Venereology Department, Tanta University, Tanta, Egypt Introduction: Hyperhidrosis is excessive sweating beyond thermoregulatory needs. It is a potentially disabling condition with challenging management. Aluminum chloride is the established topical treatment; however, response remains unsatisfactory. Oxybutynin is an anticholinergic drug that stands as a therapeutic chance for hyperhidrosis. Objectives: comparing the efficacy of topical oxybutynin 3% gel versus aluminum chloride 15% lotion in treatment of primary focal hyperhidrosis. Methods: Forty patients with hyperhidrosis were randomly distributed into 2 equal groups treated by either topical oxybutynin 3% gel or topical aluminum chloride 15% lotion once daily night application for 4 weeks (both groups). Evaluation was done at 2 and 4 weeks of treatment and after 1 month of the end of treatment for follow up by Minor iodine starch test, hyperhidrosis disease severity scale (HDSS) and dermatology life quality index (DLQI). Results: Both treatment modalities were effective with insignificant differences between patients of both groups regarding improvement in Minor iodine starch test and HDSS after 2 weeks of treatment (P = 0.561, 0.33 respectively). Oxybutynin 3% gel yielded significantly better improvement of Minor’s test, HDSS and patient’s quality of life at the end of 4 weeks of treatment with lower recurrence rate than aluminum chloride 15% lotion at 1 month follow up. Minimal adverse effects were noted in both studied groups. Conclusions: Oxybutynin 3% gel could be considered as a promising treatment modality for hyperhidrosis with higher efficacy than aluminum chloride 15% lotion and lower recurrence rate. http://dpcj.org/index.php/dpc/article/view/3067HyperhidrosisOxybutininAluminum chlorideTherapyTopical |
| spellingShingle | Amany El-Agamy El-Samadony Doaa Salah Hegab Gamal Mohamed El Maghraby Iman Hamed El-Maadawy Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis Dermatology Practical & Conceptual Hyperhidrosis Oxybutinin Aluminum chloride Therapy Topical |
| title | Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis |
| title_full | Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis |
| title_fullStr | Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis |
| title_full_unstemmed | Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis |
| title_short | Topical Oxybutynin 3% Gel versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis |
| title_sort | topical oxybutynin 3 gel versus aluminum chloride 15 lotion in treatment of primary focal hyperhidrosis |
| topic | Hyperhidrosis Oxybutinin Aluminum chloride Therapy Topical |
| url | http://dpcj.org/index.php/dpc/article/view/3067 |
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