Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood
Prenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual’s development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus that can lead to behavioral and other impairments which may la...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/8785 |
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| author | Dae D. Chung Marisa R. Pinson Lokeshwar S. Bhenderu Michael S. Lai Rhea A. Patel Rajesh C. Miranda |
| author_facet | Dae D. Chung Marisa R. Pinson Lokeshwar S. Bhenderu Michael S. Lai Rhea A. Patel Rajesh C. Miranda |
| author_sort | Dae D. Chung |
| collection | DOAJ |
| description | Prenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual’s development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus that can lead to behavioral and other impairments which may last a lifetime. Recent studies have focused on identifying mechanisms that mediate the immediate teratogenic effects of alcohol on fetal development and mechanisms that facilitate the persistent toxic effects of alcohol on health and predisposition to disease later in life. This review focuses on the contribution of epigenetic modifications and intercellular transporters like extracellular vesicles to the toxicity of PAE and to immediate and long-term consequences on an individual’s health and risk of disease. |
| first_indexed | 2024-03-10T08:45:11Z |
| format | Article |
| id | doaj.art-d25eb65e34f94e479e74d2456e1df565 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:45:11Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d25eb65e34f94e479e74d2456e1df5652023-11-22T08:00:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216878510.3390/ijms22168785Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and AdulthoodDae D. Chung0Marisa R. Pinson1Lokeshwar S. Bhenderu2Michael S. Lai3Rhea A. Patel4Rajesh C. Miranda5Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USADepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USADepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USADepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USADepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USADepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Texas A&M University, Bryan, TX 77807, USAPrenatal alcohol exposure (PAE) can have immediate and long-lasting toxic and teratogenic effects on an individual’s development and health. As a toxicant, alcohol can lead to a variety of physical and neurological anomalies in the fetus that can lead to behavioral and other impairments which may last a lifetime. Recent studies have focused on identifying mechanisms that mediate the immediate teratogenic effects of alcohol on fetal development and mechanisms that facilitate the persistent toxic effects of alcohol on health and predisposition to disease later in life. This review focuses on the contribution of epigenetic modifications and intercellular transporters like extracellular vesicles to the toxicity of PAE and to immediate and long-term consequences on an individual’s health and risk of disease.https://www.mdpi.com/1422-0067/22/16/8785prenatal alcohol exposurealcoholearly childhood adversityextracellular vesiclesdevelopmental origin of health and diseaseepigenetic modification |
| spellingShingle | Dae D. Chung Marisa R. Pinson Lokeshwar S. Bhenderu Michael S. Lai Rhea A. Patel Rajesh C. Miranda Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood International Journal of Molecular Sciences prenatal alcohol exposure alcohol early childhood adversity extracellular vesicles developmental origin of health and disease epigenetic modification |
| title | Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood |
| title_full | Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood |
| title_fullStr | Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood |
| title_full_unstemmed | Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood |
| title_short | Toxic and Teratogenic Effects of Prenatal Alcohol Exposure on Fetal Development, Adolescence, and Adulthood |
| title_sort | toxic and teratogenic effects of prenatal alcohol exposure on fetal development adolescence and adulthood |
| topic | prenatal alcohol exposure alcohol early childhood adversity extracellular vesicles developmental origin of health and disease epigenetic modification |
| url | https://www.mdpi.com/1422-0067/22/16/8785 |
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