The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor
Abstract Background It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis me...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12906-017-1888-8 |
| _version_ | 1819087881351725056 |
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| author | Chi-Chung Peng Hui-Tzu Sun I-Ping Lin Ping-Chung Kuo Jen-Chieh Li |
| author_facet | Chi-Chung Peng Hui-Tzu Sun I-Ping Lin Ping-Chung Kuo Jen-Chieh Li |
| author_sort | Chi-Chung Peng |
| collection | DOAJ |
| description | Abstract Background It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. Methods In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Furthermore, the skin whitening effect was evaluated by applying a cream product containing with 0.5%, 1% and 2% of 10-HDA onto the skin of mice (C57BL/6 J) for 3 week to observe the effect of DL*-values. Results The results showed that 10-HDA inhibited the MITF protein expression (IC50 0.86 mM) in B16F1 melanoma cells. Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related protein 1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF) in B16F1 melanoma cells. In addition, the 10-HDA was applied on the skin of mice show significantly increased the average skin-whitening index (L value). Conclusions The validation data indicated the potential of 10-HDA for use in suppressing skin pigmentation. The 10-HDA is proposed as a candidate to inhibit melanogenesis, thus it could be developed as cosmetics skin care products. |
| first_indexed | 2024-12-21T21:43:11Z |
| format | Article |
| id | doaj.art-d25ec9f6a46f4ed3ae5264c2bb48265c |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-21T21:43:11Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-d25ec9f6a46f4ed3ae5264c2bb48265c2022-12-21T18:49:18ZengBMCBMC Complementary and Alternative Medicine1472-68822017-08-011711810.1186/s12906-017-1888-8The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitorChi-Chung Peng0Hui-Tzu Sun1I-Ping Lin2Ping-Chung Kuo3Jen-Chieh Li4Department of Biotechnology, National Formosa UniversityDepartment of Biotechnology, National Formosa UniversityDepartment of Biotechnology, National Formosa UniversityDepartment of Biotechnology, National Formosa UniversityHoney Bee Town Co., Ltd.Abstract Background It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. Methods In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA. Furthermore, the skin whitening effect was evaluated by applying a cream product containing with 0.5%, 1% and 2% of 10-HDA onto the skin of mice (C57BL/6 J) for 3 week to observe the effect of DL*-values. Results The results showed that 10-HDA inhibited the MITF protein expression (IC50 0.86 mM) in B16F1 melanoma cells. Western blot analysis revealed that 10-HDA inhibited the activity of tyrosinase and the expression of tyrosinase-related protein 1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF) in B16F1 melanoma cells. In addition, the 10-HDA was applied on the skin of mice show significantly increased the average skin-whitening index (L value). Conclusions The validation data indicated the potential of 10-HDA for use in suppressing skin pigmentation. The 10-HDA is proposed as a candidate to inhibit melanogenesis, thus it could be developed as cosmetics skin care products.http://link.springer.com/article/10.1186/s12906-017-1888-8Royal jelly10-hydroxy-2-decenoic acidMelanogenesisSkin-whiteningMelanogenesis inhibitor |
| spellingShingle | Chi-Chung Peng Hui-Tzu Sun I-Ping Lin Ping-Chung Kuo Jen-Chieh Li The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor BMC Complementary and Alternative Medicine Royal jelly 10-hydroxy-2-decenoic acid Melanogenesis Skin-whitening Melanogenesis inhibitor |
| title | The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor |
| title_full | The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor |
| title_fullStr | The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor |
| title_full_unstemmed | The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor |
| title_short | The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor |
| title_sort | functional property of royal jelly 10 hydroxy 2 decenoic acid as a melanogenesis inhibitor |
| topic | Royal jelly 10-hydroxy-2-decenoic acid Melanogenesis Skin-whitening Melanogenesis inhibitor |
| url | http://link.springer.com/article/10.1186/s12906-017-1888-8 |
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