Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice
Dysregulation of high-frequency neuronal oscillations has been implicated in the pathophysiology of schizophrenia. Chronic methamphetamine (METH) use can induce psychosis similar to paranoid schizophrenia. The current study in mice aimed to determine the effect of chronic METH treatment on ongoing a...
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MDPI AG
2022-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/11/1503 |
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| author | Matthew R. Hudson Joshua Foreman Gil Rind Elizabeth E. Manning Nigel C. Jones Maarten van den Buuse |
| author_facet | Matthew R. Hudson Joshua Foreman Gil Rind Elizabeth E. Manning Nigel C. Jones Maarten van den Buuse |
| author_sort | Matthew R. Hudson |
| collection | DOAJ |
| description | Dysregulation of high-frequency neuronal oscillations has been implicated in the pathophysiology of schizophrenia. Chronic methamphetamine (METH) use can induce psychosis similar to paranoid schizophrenia. The current study in mice aimed to determine the effect of chronic METH treatment on ongoing and evoked neuronal oscillations. C57BL/6 mice were treated with METH or vehicle control for three weeks and implanted with extradural recording electrodes. Two weeks after the last METH injection, mice underwent three EEG recording sessions to measure ongoing and auditory-evoked gamma and beta oscillatory power in response to an acute challenge with METH (2 mg/kg), the NMDA receptor antagonist MK-801 (0.3 mg/kg), or saline control. A separate group of mice pretreated with METH showed significantly greater locomotor hyperactivity to an acute METH challenge, confirming long-term sensitisation. Chronic METH did not affect ongoing or evoked gamma or beta power. Acute MK-801 challenge reduced ongoing beta power whereas acute METH challenge significantly increased ongoing gamma power. Both MK-801 and METH challenge suppressed evoked gamma power. Chronic METH treatment did not modulate these acute drug effects. There were minor effects of chronic METH and acute METH and MK-801 on selected components of event-related potential (ERP) waves. In conclusion, chronic METH treatment did not exert neuroplastic effects on the regulation of cortical gamma oscillations in a manner consistent with schizophrenia, despite causing behavioural sensitisation. |
| first_indexed | 2024-03-09T19:14:36Z |
| format | Article |
| id | doaj.art-d25ef894f58a446b985a079bc396f46d |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T19:14:36Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-d25ef894f58a446b985a079bc396f46d2023-11-24T03:56:59ZengMDPI AGBrain Sciences2076-34252022-11-011211150310.3390/brainsci12111503Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious MiceMatthew R. Hudson0Joshua Foreman1Gil Rind2Elizabeth E. Manning3Nigel C. Jones4Maarten van den Buuse5Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3052, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, AustraliaDepartment of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3052, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, AustraliaDepartment of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3052, AustraliaFlorey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, AustraliaDysregulation of high-frequency neuronal oscillations has been implicated in the pathophysiology of schizophrenia. Chronic methamphetamine (METH) use can induce psychosis similar to paranoid schizophrenia. The current study in mice aimed to determine the effect of chronic METH treatment on ongoing and evoked neuronal oscillations. C57BL/6 mice were treated with METH or vehicle control for three weeks and implanted with extradural recording electrodes. Two weeks after the last METH injection, mice underwent three EEG recording sessions to measure ongoing and auditory-evoked gamma and beta oscillatory power in response to an acute challenge with METH (2 mg/kg), the NMDA receptor antagonist MK-801 (0.3 mg/kg), or saline control. A separate group of mice pretreated with METH showed significantly greater locomotor hyperactivity to an acute METH challenge, confirming long-term sensitisation. Chronic METH did not affect ongoing or evoked gamma or beta power. Acute MK-801 challenge reduced ongoing beta power whereas acute METH challenge significantly increased ongoing gamma power. Both MK-801 and METH challenge suppressed evoked gamma power. Chronic METH treatment did not modulate these acute drug effects. There were minor effects of chronic METH and acute METH and MK-801 on selected components of event-related potential (ERP) waves. In conclusion, chronic METH treatment did not exert neuroplastic effects on the regulation of cortical gamma oscillations in a manner consistent with schizophrenia, despite causing behavioural sensitisation.https://www.mdpi.com/2076-3425/12/11/1503methamphetaminemiceneural oscillationsgamma powersensitisation |
| spellingShingle | Matthew R. Hudson Joshua Foreman Gil Rind Elizabeth E. Manning Nigel C. Jones Maarten van den Buuse Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice Brain Sciences methamphetamine mice neural oscillations gamma power sensitisation |
| title | Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice |
| title_full | Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice |
| title_fullStr | Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice |
| title_full_unstemmed | Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice |
| title_short | Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice |
| title_sort | differential effects of chronic methamphetamine treatment on high frequency oscillations and responses to acute methamphetamine and nmda receptor blockade in conscious mice |
| topic | methamphetamine mice neural oscillations gamma power sensitisation |
| url | https://www.mdpi.com/2076-3425/12/11/1503 |
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