High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 w...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3946567?pdf=render |
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| author | Yi-An Zhang Ji-Min Zhu Jie Yin Wen-Qing Tang Yan-Mei Guo Xi-Zhong Shen Tao-Tao Liu |
| author_facet | Yi-An Zhang Ji-Min Zhu Jie Yin Wen-Qing Tang Yan-Mei Guo Xi-Zhong Shen Tao-Tao Liu |
| author_sort | Yi-An Zhang |
| collection | DOAJ |
| description | Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC. |
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| id | doaj.art-d262e45b4d6c42b2ad31fcdb5ee4b99c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T18:08:13Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-d262e45b4d6c42b2ad31fcdb5ee4b99c2022-12-22T00:55:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9095510.1371/journal.pone.0090955High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.Yi-An ZhangJi-Min ZhuJie YinWen-Qing TangYan-Mei GuoXi-Zhong ShenTao-Tao LiuNeuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.http://europepmc.org/articles/PMC3946567?pdf=render |
| spellingShingle | Yi-An Zhang Ji-Min Zhu Jie Yin Wen-Qing Tang Yan-Mei Guo Xi-Zhong Shen Tao-Tao Liu High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma. PLoS ONE |
| title | High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma. |
| title_full | High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma. |
| title_fullStr | High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma. |
| title_full_unstemmed | High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma. |
| title_short | High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma. |
| title_sort | high expression of neuro oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma |
| url | http://europepmc.org/articles/PMC3946567?pdf=render |
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