Renin-angiotensin system gene polymorphisms and premature coronary heart disease
Introduction Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS ge...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2005-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2005.005 |
| _version_ | 1797284947999850496 |
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| author | Cevad Sekuri F Sirri Cam Ertugrul Ercan Istemihan Tengiz Abdi Sagcan Erhan Eser Afig Berdeli Mustafa Akin |
| author_facet | Cevad Sekuri F Sirri Cam Ertugrul Ercan Istemihan Tengiz Abdi Sagcan Erhan Eser Afig Berdeli Mustafa Akin |
| author_sort | Cevad Sekuri |
| collection | DOAJ |
| description | Introduction Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population. Materials and methods One-hundred and fifteen Turkish patients with premature CHD and 128 controls were included into the study. Angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT 1 ) receptor and angiotensinogen (AGT) gene polymorphisms were analysed by polymerase chain reaction (PCR ) and restriction fragment length polymorphism (RFLP). Results The patients group showed an increased frequency of the ACE D allele compared with controls (65% vs. 35%, p=0.0001). There was a significant association between the DD genotype and premature CHD (ACE DD vs. ID and II; odds ratio [OR]=2.82 [CI 95% 1.33—2.91, p=0.002]). Also, we observed increased premature CHD risk associated with higher frequencies of the AGT MM genotype in patients when compared with controls (AGT MM vs . TT and MT, OR=1.92 [CI 95% 1.11—3.33, p=0.018]). We found a significant association between AT 1 -receptor AA genotype and decreased risk of premature CHD (AT1R AA vs . AC and CC, OR= 0.57[CI 95% 0.34—0.95, p=0.03]). Conclusions We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes. These findings indicate a synergistic contribution of ACE DD and AGT MM polymorphisms to the development of premature CHD. Also, our results suggest that family history, smoking, diabetes, hypertension, obesity and ACE DD genotype were independent risk factors for premature CHD. |
| first_indexed | 2024-03-07T17:55:10Z |
| format | Article |
| id | doaj.art-d262fd7d3324453182aa32f4ccb1b8c3 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:55:10Z |
| publishDate | 2005-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-d262fd7d3324453182aa32f4ccb1b8c32024-03-02T12:39:10ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032005-03-01610.3317/jraas.2005.005Renin-angiotensin system gene polymorphisms and premature coronary heart diseaseCevad SekuriF Sirri CamErtugrul ErcanIstemihan TengizAbdi SagcanErhan EserAfig BerdeliMustafa AkinIntroduction Experimental and clinical studies demonstrated that the renin-angiotensin system (RAS) affects the pathogenesis of atherosclerosis and prognosis of coronary heart disease (CHD). The aim of this study was to investigate the genotype distribution and the allele frequencies of three RAS genes polymorphisms and their effects on premature CHD in a Turkish population. Materials and methods One-hundred and fifteen Turkish patients with premature CHD and 128 controls were included into the study. Angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT 1 ) receptor and angiotensinogen (AGT) gene polymorphisms were analysed by polymerase chain reaction (PCR ) and restriction fragment length polymorphism (RFLP). Results The patients group showed an increased frequency of the ACE D allele compared with controls (65% vs. 35%, p=0.0001). There was a significant association between the DD genotype and premature CHD (ACE DD vs. ID and II; odds ratio [OR]=2.82 [CI 95% 1.33—2.91, p=0.002]). Also, we observed increased premature CHD risk associated with higher frequencies of the AGT MM genotype in patients when compared with controls (AGT MM vs . TT and MT, OR=1.92 [CI 95% 1.11—3.33, p=0.018]). We found a significant association between AT 1 -receptor AA genotype and decreased risk of premature CHD (AT1R AA vs . AC and CC, OR= 0.57[CI 95% 0.34—0.95, p=0.03]). Conclusions We demonstrated that increased premature CHD risk is associated with higher frequencies of the ACE DD and AGT MM genotypes. These findings indicate a synergistic contribution of ACE DD and AGT MM polymorphisms to the development of premature CHD. Also, our results suggest that family history, smoking, diabetes, hypertension, obesity and ACE DD genotype were independent risk factors for premature CHD.https://doi.org/10.3317/jraas.2005.005 |
| spellingShingle | Cevad Sekuri F Sirri Cam Ertugrul Ercan Istemihan Tengiz Abdi Sagcan Erhan Eser Afig Berdeli Mustafa Akin Renin-angiotensin system gene polymorphisms and premature coronary heart disease Journal of the Renin-Angiotensin-Aldosterone System |
| title | Renin-angiotensin system gene polymorphisms and premature coronary heart disease |
| title_full | Renin-angiotensin system gene polymorphisms and premature coronary heart disease |
| title_fullStr | Renin-angiotensin system gene polymorphisms and premature coronary heart disease |
| title_full_unstemmed | Renin-angiotensin system gene polymorphisms and premature coronary heart disease |
| title_short | Renin-angiotensin system gene polymorphisms and premature coronary heart disease |
| title_sort | renin angiotensin system gene polymorphisms and premature coronary heart disease |
| url | https://doi.org/10.3317/jraas.2005.005 |
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