Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate
Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by a drop in pH. Their established physiological and pathological roles, involving fear behaviors, learning, pain sensation, and neurodegeneration after stroke, make them promising targets for future drugs. Currently, the...
Main Authors: | Sabrina Vullo, Nicolas Ambrosio, Jan P Kucera, Olivier Bignucolo, Stephan Kellenberger |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/66488 |
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