Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists

Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists

The extracellular domain of tumor necrosis factor receptors (TNFR) generally require assembly into a homotrimeric quaternary structure as a prerequisite for initiation of signaling via the cytoplasmic domains. TNF receptor homotrimers are natively activated by similarly homo-trimerized TNF ligands,...

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Bibliographic Details
Main Authors: George Fromm, Suresh de Silva, Taylor H. Schreiber
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
TNF superfamily
agonist
TNF receptor
TNF ligand
CD40
41BB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1236332/full

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