Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses.
Objective: To investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses. AMaterials and methods:This is a...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-03-01
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| Series: | Journal of Family and Reproductive Health |
| Subjects: | |
| Online Access: | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/221 |
| _version_ | 1798027151539175424 |
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| author | Elham Azimi Nekoo Maryam Chamani Ensieh Shahrokh Tehrani Batool Hossein Rashidi Fatemeh Davari Tanha Vahid Kalantari |
| author_facet | Elham Azimi Nekoo Maryam Chamani Ensieh Shahrokh Tehrani Batool Hossein Rashidi Fatemeh Davari Tanha Vahid Kalantari |
| author_sort | Elham Azimi Nekoo |
| collection | DOAJ |
| description | Objective: To investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses.
AMaterials and methods:This is a prospective randomized clinical trial conducted in two RT centers on 176 women undergoing frozen-thawed embryo transfer. All patients received oral estradiol valerate 4 mg daily from day 2 to day 5 and 6 mg per day from day 6 to the day of the pregnancy test. In day 13 of cycle, an ultrasound examination was performed. After ultrasound confirmation of endometrial thickness (≥8 mm) and no ovarian activity, progesterone in cyclogest supp (800 mg daily) was added. The dose of estradiol would be increased to 8 mg per day if the endometrial thickness was less than 8mm. Two or 3 embryos were transferred via transcervical route 48 hours after the beginning of progesterone administration. In group A (93 patients), Difereline (3.75 mg Im), as a depot GnRH agonist was administered in the midluteal phase (day 21) of previous cycle. In the other group B (n = 83) steroid supplementation was commenced without prior pituitary suppression. Chemical and clinical pregnancy rates were compared in two groups.
Results:No significant differences were seen between two groups in terms of chemical pregnancy and clinical pregnancy rates.
Conclusion:The findings support the artificial protocol without any pretreatment suppressive drugs to reduce the adverse side effects of GnRH agonists also to minimize the costs. |
| first_indexed | 2024-04-11T18:46:44Z |
| format | Article |
| id | doaj.art-d263eb31afbb429a8505337140754cde |
| institution | Directory Open Access Journal |
| issn | 1735-8949 1735-9392 |
| language | English |
| last_indexed | 2024-04-11T18:46:44Z |
| publishDate | 2015-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Family and Reproductive Health |
| spelling | doaj.art-d263eb31afbb429a8505337140754cde2022-12-22T04:08:43ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922015-03-0191216Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses.Elham Azimi Nekoo0Maryam Chamani1Ensieh Shahrokh Tehrani2Batool Hossein Rashidi3Fatemeh Davari Tanha4Vahid Kalantari5Tehran University of Medical Sciences, Tehran, Iran.Tehran University of Medical Sciences, Tehran, Iran.Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.Women's hospital, Tehran University of Medical Sciences, Tehran, Iran.St Maarten School of Medicine, American University of Integrative Sciences, Cole Bay, St. Maarten.Objective: To investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses. AMaterials and methods:This is a prospective randomized clinical trial conducted in two RT centers on 176 women undergoing frozen-thawed embryo transfer. All patients received oral estradiol valerate 4 mg daily from day 2 to day 5 and 6 mg per day from day 6 to the day of the pregnancy test. In day 13 of cycle, an ultrasound examination was performed. After ultrasound confirmation of endometrial thickness (≥8 mm) and no ovarian activity, progesterone in cyclogest supp (800 mg daily) was added. The dose of estradiol would be increased to 8 mg per day if the endometrial thickness was less than 8mm. Two or 3 embryos were transferred via transcervical route 48 hours after the beginning of progesterone administration. In group A (93 patients), Difereline (3.75 mg Im), as a depot GnRH agonist was administered in the midluteal phase (day 21) of previous cycle. In the other group B (n = 83) steroid supplementation was commenced without prior pituitary suppression. Chemical and clinical pregnancy rates were compared in two groups. Results:No significant differences were seen between two groups in terms of chemical pregnancy and clinical pregnancy rates. Conclusion:The findings support the artificial protocol without any pretreatment suppressive drugs to reduce the adverse side effects of GnRH agonists also to minimize the costs.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/221frozen-thawed embryo transferGnRH agonistartificial cycleendometrial preparationpregnancy outcome |
| spellingShingle | Elham Azimi Nekoo Maryam Chamani Ensieh Shahrokh Tehrani Batool Hossein Rashidi Fatemeh Davari Tanha Vahid Kalantari Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses. Journal of Family and Reproductive Health frozen-thawed embryo transfer GnRH agonist artificial cycle endometrial preparation pregnancy outcome |
| title | Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses. |
| title_full | Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses. |
| title_fullStr | Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses. |
| title_full_unstemmed | Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses. |
| title_short | Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses. |
| title_sort | artificial endometrial preparation for frozen thawed embryo transfer with or without pretreatment with depot gonadotropin releasing hormone agonist in women with regular menses |
| topic | frozen-thawed embryo transfer GnRH agonist artificial cycle endometrial preparation pregnancy outcome |
| url | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/221 |
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