The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data
The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA gui...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/3/793 |
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| author | Chiara Montano Luigi Auletta Adelaide Greco Dario Costanza Pierpaolo Coluccia Chiara Del Prete Leonardo Meomartino Maria Pia Pasolini |
| author_facet | Chiara Montano Luigi Auletta Adelaide Greco Dario Costanza Pierpaolo Coluccia Chiara Del Prete Leonardo Meomartino Maria Pia Pasolini |
| author_sort | Chiara Montano |
| collection | DOAJ |
| description | The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse. |
| first_indexed | 2024-03-10T13:17:46Z |
| format | Article |
| id | doaj.art-d26585ee68854ffc8008c5252db8de1a |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T13:17:46Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-d26585ee68854ffc8008c5252db8de1a2023-11-21T10:16:25ZengMDPI AGAnimals2076-26152021-03-0111379310.3390/ani11030793The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental DataChiara Montano0Luigi Auletta1Adelaide Greco2Dario Costanza3Pierpaolo Coluccia4Chiara Del Prete5Leonardo Meomartino6Maria Pia Pasolini7Veterinary Teaching Hospital, School of Veterinary Medicine, University of Córdoba, 14004 Córdoba, SpainInstitute of Biostructure and Bioimaging, National Research Council (IBB CNR), Via T. De Amicis 95, 80145 Napoli, ItalyInterdepartmental Centre of Veterinary Radiology, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, ItalyInterdepartmental Centre of Veterinary Radiology, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, ItalyInterdepartmental Centre of Veterinary Radiology, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Production, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, ItalyInterdepartmental Centre of Veterinary Radiology, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, ItalyDepartment of Veterinary Medicine and Animal Production, University of Napoli “Federico II”, Via Federico Delpino 1, 80137 Napoli, ItalyThe use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.https://www.mdpi.com/2076-2615/11/3/793DDFTequinegrowth factorshealingligamentplatelet concentrate |
| spellingShingle | Chiara Montano Luigi Auletta Adelaide Greco Dario Costanza Pierpaolo Coluccia Chiara Del Prete Leonardo Meomartino Maria Pia Pasolini The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data Animals DDFT equine growth factors healing ligament platelet concentrate |
| title | The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data |
| title_full | The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data |
| title_fullStr | The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data |
| title_full_unstemmed | The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data |
| title_short | The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data |
| title_sort | use of platelet rich plasma for treatment of tenodesmic lesions in horses a systematic review and meta analysis of clinical and experimental data |
| topic | DDFT equine growth factors healing ligament platelet concentrate |
| url | https://www.mdpi.com/2076-2615/11/3/793 |
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