Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012
Introduction: with the screening of alpha-fetoprotein levels in maternal serum, the program has the purpose to diagnose neural tube defects and other open defects that constitute the most frequent congenital malformations in many countries and in Cuba, which makes it necessary to know its results ai...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2018-06-01
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| Series: | Revista de Ciencias Médicas de Pinar del Río |
| Subjects: | |
| Online Access: | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3524 |
| _version_ | 1818136802084519936 |
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| author | Lourdes Llambia Rodriguez Dora Castillo Silva Vivian Frontela Rodríguez María de Lourdes Hernández Llambia Aliosmy Cordero González |
| author_facet | Lourdes Llambia Rodriguez Dora Castillo Silva Vivian Frontela Rodríguez María de Lourdes Hernández Llambia Aliosmy Cordero González |
| author_sort | Lourdes Llambia Rodriguez |
| collection | DOAJ |
| description | Introduction: with the screening of alpha-fetoprotein levels in maternal serum, the program has the purpose to diagnose neural tube defects and other open defects that constitute the most frequent congenital malformations in many countries and in Cuba, which makes it necessary to know its results aimed at suggesting strategies to improve health indicators, as well as its efficiency.
Objective: to evaluate the alpha-fetoprotein screening program in maternal serum in Pinar del Río municipality from 2008 to 2012.
Method: a descriptive and retrospective-observational study that included 10 007 pregnant women who attended the municipal genetics service was conducted. Variables such as coverage, study of positivity and positive predictive values were included.
Results: 98,6 % of pregnant women underwent the study; the positivity index in 2008 was 8,95 %. The threat of abortion in 27 % was the cause of greater relation with high levels of alpha-fetoprotein, 9,09 % of positive predictive value was reached in 2012; the total of women diagnosed having fetuses with congenital defects decided to end pregnancy; 62,4 % of the congenital defects were in the closure of the neural tube and the anterior wall.
Conclusions: the maternal serum alpha-fetoprotein quantification is an effective tool in the prenatal diagnosis of congenital defects; it is possible to influence the decrease in infant mortality with the interruption of gestation of fetuses with serious congenital defects. |
| first_indexed | 2024-12-11T09:46:11Z |
| format | Article |
| id | doaj.art-d2658d683813476687b29173732f5d54 |
| institution | Directory Open Access Journal |
| issn | 1561-3194 |
| language | Spanish |
| last_indexed | 2024-12-11T09:46:11Z |
| publishDate | 2018-06-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista de Ciencias Médicas de Pinar del Río |
| spelling | doaj.art-d2658d683813476687b29173732f5d542022-12-22T01:12:34ZspaECIMEDRevista de Ciencias Médicas de Pinar del Río1561-31942018-06-01226102410321691Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012Lourdes Llambia Rodriguez0Dora Castillo Silva1Vivian Frontela Rodríguez2María de Lourdes Hernández Llambia3Aliosmy Cordero González4Policlínico Universitario Raúl Sánchez Rodríguez. Municipio Pinar del Río.Policlínico Universitario Raúl Sánchez Rodríguez. Municipio Pinar del Río.Policlínico Universitario Turcios Lima. Municipio Pinar del Río.Policlínico Universitario 5 de septiembre, Municipio Consolación del Sur.Facultad de Ciencias Médicas Ernesto Guevara de la Serna, Pinar del Río.Introduction: with the screening of alpha-fetoprotein levels in maternal serum, the program has the purpose to diagnose neural tube defects and other open defects that constitute the most frequent congenital malformations in many countries and in Cuba, which makes it necessary to know its results aimed at suggesting strategies to improve health indicators, as well as its efficiency. Objective: to evaluate the alpha-fetoprotein screening program in maternal serum in Pinar del Río municipality from 2008 to 2012. Method: a descriptive and retrospective-observational study that included 10 007 pregnant women who attended the municipal genetics service was conducted. Variables such as coverage, study of positivity and positive predictive values were included. Results: 98,6 % of pregnant women underwent the study; the positivity index in 2008 was 8,95 %. The threat of abortion in 27 % was the cause of greater relation with high levels of alpha-fetoprotein, 9,09 % of positive predictive value was reached in 2012; the total of women diagnosed having fetuses with congenital defects decided to end pregnancy; 62,4 % of the congenital defects were in the closure of the neural tube and the anterior wall. Conclusions: the maternal serum alpha-fetoprotein quantification is an effective tool in the prenatal diagnosis of congenital defects; it is possible to influence the decrease in infant mortality with the interruption of gestation of fetuses with serious congenital defects.http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3524DEFECTOS DEL TUBO NEURALASESORAMIENTO GENÉTICOANOMALÍAS CONGÉNITAS/diagnósticoLÍQUIDO AMNIÓTICO. |
| spellingShingle | Lourdes Llambia Rodriguez Dora Castillo Silva Vivian Frontela Rodríguez María de Lourdes Hernández Llambia Aliosmy Cordero González Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012 Revista de Ciencias Médicas de Pinar del Río DEFECTOS DEL TUBO NEURAL ASESORAMIENTO GENÉTICO ANOMALÍAS CONGÉNITAS/diagnóstico LÍQUIDO AMNIÓTICO. |
| title | Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012 |
| title_full | Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012 |
| title_fullStr | Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012 |
| title_full_unstemmed | Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012 |
| title_short | Results of the program Alpha-Fetoprotein in Maternal Serum, Pinar del Río municipality, 2008 - 2012 |
| title_sort | results of the program alpha fetoprotein in maternal serum pinar del rio municipality 2008 2012 |
| topic | DEFECTOS DEL TUBO NEURAL ASESORAMIENTO GENÉTICO ANOMALÍAS CONGÉNITAS/diagnóstico LÍQUIDO AMNIÓTICO. |
| url | http://www.revcmpinar.sld.cu/index.php/publicaciones/article/view/3524 |
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