Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle
In a majority of mammals, male infants have heavier body mass and grow faster than female infants. Accordingly, male offspring nursing requires a much greater maternal energy contribution to lactation. It is possible that the maternal-fetal immunoendocrine dialog plays an important role in female pr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian-Australasian Association of Animal Production Societies
2013-10-01
|
| Series: | Asian-Australasian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | http://www.ajas.info/upload/pdf/ajas-26-10-1379-4.pdf |
| _version_ | 1811322368945029120 |
|---|---|
| author | N. S. Yudin R. B. Aitnazarov M. I. Voevoda L. A. Gerlinskaya M. P. Moshkin |
| author_facet | N. S. Yudin R. B. Aitnazarov M. I. Voevoda L. A. Gerlinskaya M. P. Moshkin |
| author_sort | N. S. Yudin |
| collection | DOAJ |
| description | In a majority of mammals, male infants have heavier body mass and grow faster than female infants. Accordingly, male offspring nursing requires a much greater maternal energy contribution to lactation. It is possible that the maternal-fetal immunoendocrine dialog plays an important role in female preparation for lactation during pregnancy. Immune system genes are an integral part of gene regulatory networks in lactation and tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine that also plays an important role in normal mammary gland development. The aim of this study was to evaluate the influence of the sex of calf and/or the -824A/G polymorphism in the promoter region of TNFα gene on milk performance traits in Black Pied cattle over the course of lactation. We also studied the allele frequency differences of -824A/G variants across several cattle breeds, which were bred in different climatic conditions. The G allele frequency decreased gradually over the course of lactation events in the Black Pied dairy cattle because of a higher culling rate of cows with the G/G genotype (p<0.001). In contrast to the genotypes A/A and A/G, cows with G/G genotype showed significant variability of milk and milk fat yield subject to sex of delivered calf. Milk yield and milk fat yield were significantly higher in the case of birth of a bull calf than with a heifer calf (p<0.03). The G allele frequency varies from 48% to 58% in Grey Ukrainian and Black Pied cattle to 77% in aboriginal Yakut cattle. Our results suggest that the TNFα -824A/G gene polymorphism may have an influence on the reproductive efforts of cows over the course of lactation events depending on the sex of progeny. Allocation of resources according to sex of the calf allows optimizing the energy cost of lactation. This may be a probable reason for high G allele frequency in Yakut cattle breeding in extreme environmental conditions. Similarly, the dramatic fall in milk production after birth of a heifer calf increases the probability of culling for the cows with the G/G genotype in animal husbandry. |
| first_indexed | 2024-04-13T13:34:04Z |
| format | Article |
| id | doaj.art-d265af8beb94425890e1e39e3a057902 |
| institution | Directory Open Access Journal |
| issn | 1011-2367 1976-5517 |
| language | English |
| last_indexed | 2024-04-13T13:34:04Z |
| publishDate | 2013-10-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Asian-Australasian Journal of Animal Sciences |
| spelling | doaj.art-d265af8beb94425890e1e39e3a0579022022-12-22T02:44:51ZengAsian-Australasian Association of Animal Production SocietiesAsian-Australasian Journal of Animal Sciences1011-23671976-55172013-10-0126101379138710.5713/ajas.2013.131144582Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in CattleN. S. Yudin0R. B. Aitnazarov1M. I. VoevodaL. A. GerlinskayaM. P. Moshkin2 Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences,Novosibirsk 630090, Russian Federation Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences,Novosibirsk 630090, Russian Federation Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences,Novosibirsk 630090, Russian FederationIn a majority of mammals, male infants have heavier body mass and grow faster than female infants. Accordingly, male offspring nursing requires a much greater maternal energy contribution to lactation. It is possible that the maternal-fetal immunoendocrine dialog plays an important role in female preparation for lactation during pregnancy. Immune system genes are an integral part of gene regulatory networks in lactation and tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine that also plays an important role in normal mammary gland development. The aim of this study was to evaluate the influence of the sex of calf and/or the -824A/G polymorphism in the promoter region of TNFα gene on milk performance traits in Black Pied cattle over the course of lactation. We also studied the allele frequency differences of -824A/G variants across several cattle breeds, which were bred in different climatic conditions. The G allele frequency decreased gradually over the course of lactation events in the Black Pied dairy cattle because of a higher culling rate of cows with the G/G genotype (p<0.001). In contrast to the genotypes A/A and A/G, cows with G/G genotype showed significant variability of milk and milk fat yield subject to sex of delivered calf. Milk yield and milk fat yield were significantly higher in the case of birth of a bull calf than with a heifer calf (p<0.03). The G allele frequency varies from 48% to 58% in Grey Ukrainian and Black Pied cattle to 77% in aboriginal Yakut cattle. Our results suggest that the TNFα -824A/G gene polymorphism may have an influence on the reproductive efforts of cows over the course of lactation events depending on the sex of progeny. Allocation of resources according to sex of the calf allows optimizing the energy cost of lactation. This may be a probable reason for high G allele frequency in Yakut cattle breeding in extreme environmental conditions. Similarly, the dramatic fall in milk production after birth of a heifer calf increases the probability of culling for the cows with the G/G genotype in animal husbandry.http://www.ajas.info/upload/pdf/ajas-26-10-1379-4.pdfCattle GeneSingle Nucleotide PolymorphismMilk ProductionSex of Progeny |
| spellingShingle | N. S. Yudin R. B. Aitnazarov M. I. Voevoda L. A. Gerlinskaya M. P. Moshkin Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle Asian-Australasian Journal of Animal Sciences Cattle Gene Single Nucleotide Polymorphism Milk Production Sex of Progeny |
| title | Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle |
| title_full | Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle |
| title_fullStr | Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle |
| title_full_unstemmed | Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle |
| title_short | Association of Polymorphism Harbored by Tumor Necrosis Factor Alpha Gene and Sex of Calf with Lactation Performance in Cattle |
| title_sort | association of polymorphism harbored by tumor necrosis factor alpha gene and sex of calf with lactation performance in cattle |
| topic | Cattle Gene Single Nucleotide Polymorphism Milk Production Sex of Progeny |
| url | http://www.ajas.info/upload/pdf/ajas-26-10-1379-4.pdf |
| work_keys_str_mv | AT nsyudin associationofpolymorphismharboredbytumornecrosisfactoralphageneandsexofcalfwithlactationperformanceincattle AT rbaitnazarov associationofpolymorphismharboredbytumornecrosisfactoralphageneandsexofcalfwithlactationperformanceincattle AT mivoevoda associationofpolymorphismharboredbytumornecrosisfactoralphageneandsexofcalfwithlactationperformanceincattle AT lagerlinskaya associationofpolymorphismharboredbytumornecrosisfactoralphageneandsexofcalfwithlactationperformanceincattle AT mpmoshkin associationofpolymorphismharboredbytumornecrosisfactoralphageneandsexofcalfwithlactationperformanceincattle |