Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis
Abstract Background and objective More than five million individuals died because of problems connected to COVID-19. SARS-Cov-2 poses a particular challenge to expectant mothers, who comprise one of the most vulnerable segments of the population. Our aim is to demonstrate the maternal and neonatal s...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-022-04884-9 |
| _version_ | 1818509983488147456 |
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| author | Abdulrahman Ibrahim Hagrass Hossam Waleed Almadhoon Mohammed Al-kafarna Bashar Khaled Almaghary Anas Zakarya Nourelden Ahmed Hashem Fathallah Mohammed Tarek Hasan Yasmine Adel Mohammed Aya Osama Al-Nabahin Dalia Sami Wafi Islam Osama Ismail Yaser Aref Hamam Reem Sayad Mohamed Hamouda Mohamed Sayed Zaazouee Khaled Mohamed Ragab |
| author_facet | Abdulrahman Ibrahim Hagrass Hossam Waleed Almadhoon Mohammed Al-kafarna Bashar Khaled Almaghary Anas Zakarya Nourelden Ahmed Hashem Fathallah Mohammed Tarek Hasan Yasmine Adel Mohammed Aya Osama Al-Nabahin Dalia Sami Wafi Islam Osama Ismail Yaser Aref Hamam Reem Sayad Mohamed Hamouda Mohamed Sayed Zaazouee Khaled Mohamed Ragab |
| author_sort | Abdulrahman Ibrahim Hagrass |
| collection | DOAJ |
| description | Abstract Background and objective More than five million individuals died because of problems connected to COVID-19. SARS-Cov-2 poses a particular challenge to expectant mothers, who comprise one of the most vulnerable segments of the population. Our aim is to demonstrate the maternal and neonatal safety of the COVID-19 vaccine during pregnancy. Methods We searched PubMed, Cochrane Library, Scopus, Web of Science (WOS), Embase, Ovid, MedRxiv, and BioRxiv databases from inception till December 2021 and then updated it in April 2022. Additionally, we searched ClinicalTrials.gov, Research Square and grey literature. Cohort, case–control studies, and randomized controlled trials detecting the safety of the Covid-19 vaccine during pregnancy were included. We used the Cochrane tool and Newcastle–Ottawa Scale to assess the risk of bias of the included studies and the GRADE scale to assess the quality of evidence. A meta-analysis was conducted using review manager 5.4. Results We included 13 studies with a total number of 56,428 patients. Our analysis showed no statistically significant difference in the following outcomes: miscarriage (1.56% vs 0.3%. RR 1.23; 95%CI 0.54 to 2.78); length of maternal hospitalization (MD 0.00; 95%CI -0.08 to 0.08); puerperal fever (1.71% vs 1.1%. RR 1.04; 95%CI 0.67 to 1.61); postpartum hemorrhage (4.27% vs 3.52%. RR 0.84; 95%CI 0.65 to 1.09); instrumental or vacuum-assisted delivery (4.16% vs 4.54%. RR 0.94; 95%CI 0.57 to 1.56); incidence of Apgar score ≤ 7 at 5 min (1.47% vs 1.48%. RR 0.86; 95%CI 0.54 to 1.37); and birthweight (MD -7.14; 95%CI -34.26 to 19.99). Conclusion In pregnancy, the current meta-analysis shows no effect of SAR-CoV-2 vaccination on the risk of miscarriage, length of stay in the hospital, puerperal fever, postpartum hemorrhage, birth weight, or the incidence of an Apgar score of ≤ 7 at 5 min. |
| first_indexed | 2024-12-10T22:52:56Z |
| format | Article |
| id | doaj.art-d268fc0e7502405f99bf026a7d141d6a |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-10T22:52:56Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-d268fc0e7502405f99bf026a7d141d6a2022-12-22T01:30:21ZengBMCBMC Pregnancy and Childbirth1471-23932022-07-0122111910.1186/s12884-022-04884-9Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysisAbdulrahman Ibrahim Hagrass0Hossam Waleed Almadhoon1Mohammed Al-kafarna2Bashar Khaled Almaghary3Anas Zakarya Nourelden4Ahmed Hashem Fathallah5Mohammed Tarek Hasan6Yasmine Adel Mohammed7Aya Osama Al-Nabahin8Dalia Sami Wafi9Islam Osama Ismail10Yaser Aref Hamam11Reem Sayad12Mohamed Hamouda13Mohamed Sayed Zaazouee14Khaled Mohamed Ragab15Faculty of Medicine, Al-Azhar UniversityFaculty of Dentistry, Al-Azhar UniversityFaculty of Pharmacy, Al-Azhar UniversityFaculty of Pharmacy, Al-Azhar UniversityFaculty of Medicine, Al-Azhar UniversityFaculty of Medicine, Minia UniversityFaculty of Medicine, Al-Azhar UniversityFaculty of Medicine, Assiut UniversityDepartment of Clinical Nutrition, Faculty of Applied Medical Sciences, Al-Azhar UniversityFaculty of Medicine, Al-Quds UniversityFaculty of Medicine, Al-Quds UniversityFaculty of Medicine, Al-Quds UniversityFaculty of Medicine, Assiut UniversityFaculty of Medicine, Al-Azhar UniversityFaculty of Medicine, Al-Azhar UniversityFaculty of Medicine, Minia UniversityAbstract Background and objective More than five million individuals died because of problems connected to COVID-19. SARS-Cov-2 poses a particular challenge to expectant mothers, who comprise one of the most vulnerable segments of the population. Our aim is to demonstrate the maternal and neonatal safety of the COVID-19 vaccine during pregnancy. Methods We searched PubMed, Cochrane Library, Scopus, Web of Science (WOS), Embase, Ovid, MedRxiv, and BioRxiv databases from inception till December 2021 and then updated it in April 2022. Additionally, we searched ClinicalTrials.gov, Research Square and grey literature. Cohort, case–control studies, and randomized controlled trials detecting the safety of the Covid-19 vaccine during pregnancy were included. We used the Cochrane tool and Newcastle–Ottawa Scale to assess the risk of bias of the included studies and the GRADE scale to assess the quality of evidence. A meta-analysis was conducted using review manager 5.4. Results We included 13 studies with a total number of 56,428 patients. Our analysis showed no statistically significant difference in the following outcomes: miscarriage (1.56% vs 0.3%. RR 1.23; 95%CI 0.54 to 2.78); length of maternal hospitalization (MD 0.00; 95%CI -0.08 to 0.08); puerperal fever (1.71% vs 1.1%. RR 1.04; 95%CI 0.67 to 1.61); postpartum hemorrhage (4.27% vs 3.52%. RR 0.84; 95%CI 0.65 to 1.09); instrumental or vacuum-assisted delivery (4.16% vs 4.54%. RR 0.94; 95%CI 0.57 to 1.56); incidence of Apgar score ≤ 7 at 5 min (1.47% vs 1.48%. RR 0.86; 95%CI 0.54 to 1.37); and birthweight (MD -7.14; 95%CI -34.26 to 19.99). Conclusion In pregnancy, the current meta-analysis shows no effect of SAR-CoV-2 vaccination on the risk of miscarriage, length of stay in the hospital, puerperal fever, postpartum hemorrhage, birth weight, or the incidence of an Apgar score of ≤ 7 at 5 min.https://doi.org/10.1186/s12884-022-04884-9COVID-19 vaccinePregnancyMaternalNeonatalSafety |
| spellingShingle | Abdulrahman Ibrahim Hagrass Hossam Waleed Almadhoon Mohammed Al-kafarna Bashar Khaled Almaghary Anas Zakarya Nourelden Ahmed Hashem Fathallah Mohammed Tarek Hasan Yasmine Adel Mohammed Aya Osama Al-Nabahin Dalia Sami Wafi Islam Osama Ismail Yaser Aref Hamam Reem Sayad Mohamed Hamouda Mohamed Sayed Zaazouee Khaled Mohamed Ragab Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis BMC Pregnancy and Childbirth COVID-19 vaccine Pregnancy Maternal Neonatal Safety |
| title | Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis |
| title_full | Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis |
| title_fullStr | Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis |
| title_full_unstemmed | Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis |
| title_short | Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis |
| title_sort | maternal and neonatal safety outcomes after sar cov 2 vaccination during pregnancy a systematic review and meta analysis |
| topic | COVID-19 vaccine Pregnancy Maternal Neonatal Safety |
| url | https://doi.org/10.1186/s12884-022-04884-9 |
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