Fixing the GAP: The role of RhoGAPs in cancer
Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins. Rho GTPases are signaling proteins that function as molecular switches and are involved in the regulation of most...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | European Journal of Cell Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933522000127 |
| _version_ | 1828815588783292416 |
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| author | Gabriel Kreider-Letterman Nicole M. Carr Rafael Garcia-Mata |
| author_facet | Gabriel Kreider-Letterman Nicole M. Carr Rafael Garcia-Mata |
| author_sort | Gabriel Kreider-Letterman |
| collection | DOAJ |
| description | Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins. Rho GTPases are signaling proteins that function as molecular switches and are involved in the regulation of most major cellular processes. Cancer development is often associated with abnormalities in Rho GTPase signaling. Rho GTPase signaling is regulated by two families of proteins, guanine nucleotide-exchange factors (RhoGEFs) and GTPase activating proteins (RhoGAPs), that function upstream of the Rho proteins to regulate their activation and inactivation, respectively. While initial work has focused on the role of RhoGEFs in cancer, the RhoGAP family members are rapidly being established as key regulators of cancer development and progression. The aim of this review is to summarize our advances in understanding the role of RhoGAPs in cancer and to discuss their significance in the development of therapeutics. |
| first_indexed | 2024-12-12T10:47:37Z |
| format | Article |
| id | doaj.art-d26a429815c049f4a4ac56604baa502f |
| institution | Directory Open Access Journal |
| issn | 0171-9335 |
| language | English |
| last_indexed | 2024-12-12T10:47:37Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj.art-d26a429815c049f4a4ac56604baa502f2022-12-22T00:26:51ZengElsevierEuropean Journal of Cell Biology0171-93352022-04-011012151209Fixing the GAP: The role of RhoGAPs in cancerGabriel Kreider-Letterman0Nicole M. Carr1Rafael Garcia-Mata2Department of Biological Sciences, The University of Toledo, Toledo OH, USADepartment of Biological Sciences, The University of Toledo, Toledo OH, USACorresponding author.; Department of Biological Sciences, The University of Toledo, Toledo OH, USACancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins. Rho GTPases are signaling proteins that function as molecular switches and are involved in the regulation of most major cellular processes. Cancer development is often associated with abnormalities in Rho GTPase signaling. Rho GTPase signaling is regulated by two families of proteins, guanine nucleotide-exchange factors (RhoGEFs) and GTPase activating proteins (RhoGAPs), that function upstream of the Rho proteins to regulate their activation and inactivation, respectively. While initial work has focused on the role of RhoGEFs in cancer, the RhoGAP family members are rapidly being established as key regulators of cancer development and progression. The aim of this review is to summarize our advances in understanding the role of RhoGAPs in cancer and to discuss their significance in the development of therapeutics.http://www.sciencedirect.com/science/article/pii/S0171933522000127RhoGAPsRho GTPasesCancerMetastasisOncogeneTumor suppressor |
| spellingShingle | Gabriel Kreider-Letterman Nicole M. Carr Rafael Garcia-Mata Fixing the GAP: The role of RhoGAPs in cancer European Journal of Cell Biology RhoGAPs Rho GTPases Cancer Metastasis Oncogene Tumor suppressor |
| title | Fixing the GAP: The role of RhoGAPs in cancer |
| title_full | Fixing the GAP: The role of RhoGAPs in cancer |
| title_fullStr | Fixing the GAP: The role of RhoGAPs in cancer |
| title_full_unstemmed | Fixing the GAP: The role of RhoGAPs in cancer |
| title_short | Fixing the GAP: The role of RhoGAPs in cancer |
| title_sort | fixing the gap the role of rhogaps in cancer |
| topic | RhoGAPs Rho GTPases Cancer Metastasis Oncogene Tumor suppressor |
| url | http://www.sciencedirect.com/science/article/pii/S0171933522000127 |
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