Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis
Objectives: Mammographic density is a well-defined risk factor for breast cancer and having extremely dense breast tissue is associated with a one-to six-fold increased risk of breast cancer. However, it is questioned whether this increased risk estimate is applicable to current breast density class...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Breast |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977622001618 |
| _version_ | 1797979769316311040 |
|---|---|
| author | F.T.H. Bodewes A.A. van Asselt M.D. Dorrius M.J.W. Greuter G.H. de Bock |
| author_facet | F.T.H. Bodewes A.A. van Asselt M.D. Dorrius M.J.W. Greuter G.H. de Bock |
| author_sort | F.T.H. Bodewes |
| collection | DOAJ |
| description | Objectives: Mammographic density is a well-defined risk factor for breast cancer and having extremely dense breast tissue is associated with a one-to six-fold increased risk of breast cancer. However, it is questioned whether this increased risk estimate is applicable to current breast density classification methods. Therefore, the aim of this study was to further investigate and clarify the association between mammographic density and breast cancer risk based on current literature. Methods: Medline, Embase and Web of Science were systematically searched for articles published since 2013, that used BI-RADS lexicon 5th edition and incorporated data on digital mammography. Crude and maximally confounder-adjusted data were pooled in odds ratios (ORs) using random-effects models. Heterogeneity regarding breast cancer risks were investigated using I2 statistic, stratified and sensitivity analyses. Results: Nine observational studies were included. Having extremely dense breast tissue (BI-RADS density D) resulted in a 2.11-fold (95% CI 1.84–2.42) increased breast cancer risk compared to having scattered dense breast tissue (BI-RADS density B). Sensitivity analysis showed that when only using data that had adjusted for age and BMI, the breast cancer risk was 1.83-fold (95% CI 1.52–2.21) increased. Both results were statistically significant and homogenous. Conclusions: Mammographic breast density BI-RADS D is associated with an approximately two-fold increased risk of breast cancer compared to having BI-RADS density B in general population women. This is a novel and lower risk estimate compared to previously reported and might be explained due to the use of digital mammography and BI-RADS lexicon 5th edition. |
| first_indexed | 2024-04-11T05:43:58Z |
| format | Article |
| id | doaj.art-d26b0fbba4884011a8f360f625fd9972 |
| institution | Directory Open Access Journal |
| issn | 1532-3080 |
| language | English |
| last_indexed | 2024-04-11T05:43:58Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj.art-d26b0fbba4884011a8f360f625fd99722022-12-22T04:42:19ZengElsevierBreast1532-30802022-12-01666268Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysisF.T.H. Bodewes0A.A. van Asselt1M.D. Dorrius2M.J.W. Greuter3G.H. de Bock4Department of Epidemiology, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, HPC: FA40, PO Box 30.001, Groningen, 9700 RB, the NetherlandsDepartment of Epidemiology, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, HPC: FA40, PO Box 30.001, Groningen, 9700 RB, the NetherlandsDepartment of Radiology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the NetherlandsDepartment of Radiology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the NetherlandsDepartment of Epidemiology, University Medical Center Groningen (UMCG), University of Groningen, Hanzeplein 1, HPC: FA40, PO Box 30.001, Groningen, 9700 RB, the Netherlands; Corresponding author.Objectives: Mammographic density is a well-defined risk factor for breast cancer and having extremely dense breast tissue is associated with a one-to six-fold increased risk of breast cancer. However, it is questioned whether this increased risk estimate is applicable to current breast density classification methods. Therefore, the aim of this study was to further investigate and clarify the association between mammographic density and breast cancer risk based on current literature. Methods: Medline, Embase and Web of Science were systematically searched for articles published since 2013, that used BI-RADS lexicon 5th edition and incorporated data on digital mammography. Crude and maximally confounder-adjusted data were pooled in odds ratios (ORs) using random-effects models. Heterogeneity regarding breast cancer risks were investigated using I2 statistic, stratified and sensitivity analyses. Results: Nine observational studies were included. Having extremely dense breast tissue (BI-RADS density D) resulted in a 2.11-fold (95% CI 1.84–2.42) increased breast cancer risk compared to having scattered dense breast tissue (BI-RADS density B). Sensitivity analysis showed that when only using data that had adjusted for age and BMI, the breast cancer risk was 1.83-fold (95% CI 1.52–2.21) increased. Both results were statistically significant and homogenous. Conclusions: Mammographic breast density BI-RADS D is associated with an approximately two-fold increased risk of breast cancer compared to having BI-RADS density B in general population women. This is a novel and lower risk estimate compared to previously reported and might be explained due to the use of digital mammography and BI-RADS lexicon 5th edition.http://www.sciencedirect.com/science/article/pii/S0960977622001618Breast cancer riskBreast cancerBreast densityMammographic densityBI-RADS |
| spellingShingle | F.T.H. Bodewes A.A. van Asselt M.D. Dorrius M.J.W. Greuter G.H. de Bock Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis Breast Breast cancer risk Breast cancer Breast density Mammographic density BI-RADS |
| title | Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis |
| title_full | Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis |
| title_fullStr | Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis |
| title_short | Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis |
| title_sort | mammographic breast density and the risk of breast cancer a systematic review and meta analysis |
| topic | Breast cancer risk Breast cancer Breast density Mammographic density BI-RADS |
| url | http://www.sciencedirect.com/science/article/pii/S0960977622001618 |
| work_keys_str_mv | AT fthbodewes mammographicbreastdensityandtheriskofbreastcancerasystematicreviewandmetaanalysis AT aavanasselt mammographicbreastdensityandtheriskofbreastcancerasystematicreviewandmetaanalysis AT mddorrius mammographicbreastdensityandtheriskofbreastcancerasystematicreviewandmetaanalysis AT mjwgreuter mammographicbreastdensityandtheriskofbreastcancerasystematicreviewandmetaanalysis AT ghdebock mammographicbreastdensityandtheriskofbreastcancerasystematicreviewandmetaanalysis |