Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis

Prophylactic approaches to graft versus host disease (GvHD) have employed both phenotypic reduction of T cells and selective elimination of host-primed donor T cells in vitro and in vivo. An additional approach to GvHD prophylaxis by functional depletion of apoptosis-sensitive donor T cells without...

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Bibliographic Details
Main Authors: Shai eYarkoni, Jerry eStein, Isaac eYaniv, Nadir eAskenasy
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
Apoptosis
Fas
graft versus host disease
T cell depletion
TNF receptors
antigen-specific stimulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00215/full

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