DROSHA but not DICER is required for human haematopoietic stem cell function

DROSHA but not DICER is required for human haematopoietic stem cell function

Abstract Objectives DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the murine system, DROSHA has an alternate function where it directly recognises and cleaves protein‐coding messenger (m)RNAs and this is critical for safeguarding t...

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Bibliographic Details
Main Authors: Karen Gu, Carina Walpole, Shayarana Gooneratne, Xin Liu, Oscar L Haigh, Kristen J Radford, Mark MW Chong
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
DICER
DROSHA
haematopoietic stem cells
microRNA
mRNA
Online Access:https://doi.org/10.1002/cti2.1361

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