Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats
Background: The effect of periodic exposure to formaldehyde on some haematological indices in male Wistar rat was studied. Materials and Methods: The Wistar rats were divided into three groups A,B and C with 5 animals in each group. Group A served as control with nil exposure while groups B and...
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| Format: | Article |
| Language: | English |
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Nigerian Medical Association, Akwa Ibom State Branch
2023-09-01
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| Series: | Ibom Medical Journal |
| Subjects: | |
| Online Access: | https://ibommedicaljournal.org/index.php/imjhome/article/view/347 |
| _version_ | 1797271971350708224 |
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| author | Ebojele FO Iyawe VI |
| author_facet | Ebojele FO Iyawe VI |
| author_sort | Ebojele FO |
| collection | DOAJ |
| description |
Background: The effect of periodic exposure to formaldehyde on some haematological indices in male Wistar rat was studied.
Materials and Methods: The Wistar rats were divided into three groups A,B and C with 5 animals in each group. Group A served as control with nil exposure while groups B and C were the test groups with 5 months exposure on non-dissection days and dissection days respectively. Formaldehyde air level was measured both at experimental and control sites. Some haematological parameters measured include Red blood cell count, Haemoglobin concentration, White blood cell count: total and differential, and platelet count. Statistical analysis was done using Graph Pad Prism version 5.0. Results were presented as Mean ± SEM. Analysis of Variance was used to compare the means of test and control values while post hoc test was done using Student Newman Keul’s test and a P-value of less than 0.05 was considered as statistically significant.
Results: Results revealed significant increase in formaldehyde air level in the dissection hall. There was significant increase in total white blood cell count when compared with control while red blood cell count, haemoglobin concentration and platelet count were not significant.
Conclusion: It was therefore concluded that periodic exposure to formaldehyde in the Anatomy laboratory may have no effect on most haematological indices in Wistar rats although the white blood cells may be affected.
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| first_indexed | 2024-03-07T14:16:53Z |
| format | Article |
| id | doaj.art-d2700bda17934a1f9683b1ee12dc2f35 |
| institution | Directory Open Access Journal |
| issn | 1597-7188 2735-9964 |
| language | English |
| last_indexed | 2024-03-07T14:16:53Z |
| publishDate | 2023-09-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj.art-d2700bda17934a1f9683b1ee12dc2f352024-03-06T11:55:13ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642023-09-0116310.61386/imj.v16i3.347Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar ratsEbojele FO0Iyawe VI1Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, NigeriaDepartment of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria Background: The effect of periodic exposure to formaldehyde on some haematological indices in male Wistar rat was studied. Materials and Methods: The Wistar rats were divided into three groups A,B and C with 5 animals in each group. Group A served as control with nil exposure while groups B and C were the test groups with 5 months exposure on non-dissection days and dissection days respectively. Formaldehyde air level was measured both at experimental and control sites. Some haematological parameters measured include Red blood cell count, Haemoglobin concentration, White blood cell count: total and differential, and platelet count. Statistical analysis was done using Graph Pad Prism version 5.0. Results were presented as Mean ± SEM. Analysis of Variance was used to compare the means of test and control values while post hoc test was done using Student Newman Keul’s test and a P-value of less than 0.05 was considered as statistically significant. Results: Results revealed significant increase in formaldehyde air level in the dissection hall. There was significant increase in total white blood cell count when compared with control while red blood cell count, haemoglobin concentration and platelet count were not significant. Conclusion: It was therefore concluded that periodic exposure to formaldehyde in the Anatomy laboratory may have no effect on most haematological indices in Wistar rats although the white blood cells may be affected. https://ibommedicaljournal.org/index.php/imjhome/article/view/347periodicformaldehydehaematologicalWistar rats |
| spellingShingle | Ebojele FO Iyawe VI Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats Ibom Medical Journal periodic formaldehyde haematological Wistar rats |
| title | Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats |
| title_full | Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats |
| title_fullStr | Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats |
| title_full_unstemmed | Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats |
| title_short | Effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male Wistar rats |
| title_sort | effect of periodic exposure to formaldehyde in the anatomy laboratory on some haematological indices in male wistar rats |
| topic | periodic formaldehyde haematological Wistar rats |
| url | https://ibommedicaljournal.org/index.php/imjhome/article/view/347 |
| work_keys_str_mv | AT ebojelefo effectofperiodicexposuretoformaldehydeintheanatomylaboratoryonsomehaematologicalindicesinmalewistarrats AT iyawevi effectofperiodicexposuretoformaldehydeintheanatomylaboratoryonsomehaematologicalindicesinmalewistarrats |