Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contrala...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/42992 |
| _version_ | 1829097387866456064 |
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| author | Rachel S Lee Marcelo G Mattar Nathan F Parker Ilana B Witten Nathaniel D Daw |
| author_facet | Rachel S Lee Marcelo G Mattar Nathan F Parker Ilana B Witten Nathaniel D Daw |
| author_sort | Rachel S Lee |
| collection | DOAJ |
| description | Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contralateral to the recording side. Here, we introduce, and ultimately reject, a candidate resolution for the puzzling RPE vs movement dichotomy, by showing how seemingly movement-related activity might be explained by an action-specific RPE. By considering both choice and RPE on a trial-by-trial basis, we find that DA signals are modulated by contralateral choice in a manner that is distinct from RPE, implying that choice encoding is better explained by movement direction. This fundamental separation between RPE and movement encoding may help shed light on the diversity of functions and dysfunctions of the DA system. |
| first_indexed | 2024-04-11T09:13:12Z |
| format | Article |
| id | doaj.art-d27199bcf28642ffa8306a8ebae6ef94 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:13:12Z |
| publishDate | 2019-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d27199bcf28642ffa8306a8ebae6ef942022-12-22T04:32:27ZengeLife Sciences Publications LtdeLife2050-084X2019-04-01810.7554/eLife.42992Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neuronsRachel S Lee0https://orcid.org/0000-0001-7984-1942Marcelo G Mattar1Nathan F Parker2Ilana B Witten3https://orcid.org/0000-0003-0548-2160Nathaniel D Daw4https://orcid.org/0000-0001-5029-1430Department of Psychology, Princeton Neuroscience Institute, Princeton University, New Jersey, United StatesDepartment of Psychology, Princeton Neuroscience Institute, Princeton University, New Jersey, United StatesDepartment of Psychology, Princeton Neuroscience Institute, Princeton University, New Jersey, United StatesDepartment of Psychology, Princeton Neuroscience Institute, Princeton University, New Jersey, United StatesDepartment of Psychology, Princeton Neuroscience Institute, Princeton University, New Jersey, United StatesAlthough midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contralateral to the recording side. Here, we introduce, and ultimately reject, a candidate resolution for the puzzling RPE vs movement dichotomy, by showing how seemingly movement-related activity might be explained by an action-specific RPE. By considering both choice and RPE on a trial-by-trial basis, we find that DA signals are modulated by contralateral choice in a manner that is distinct from RPE, implying that choice encoding is better explained by movement direction. This fundamental separation between RPE and movement encoding may help shed light on the diversity of functions and dysfunctions of the DA system.https://elifesciences.org/articles/42992dopaminereward prediction errorvalue |
| spellingShingle | Rachel S Lee Marcelo G Mattar Nathan F Parker Ilana B Witten Nathaniel D Daw Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons eLife dopamine reward prediction error value |
| title | Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons |
| title_full | Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons |
| title_fullStr | Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons |
| title_full_unstemmed | Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons |
| title_short | Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons |
| title_sort | reward prediction error does not explain movement selectivity in dms projecting dopamine neurons |
| topic | dopamine reward prediction error value |
| url | https://elifesciences.org/articles/42992 |
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