Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease
<p>Abstract</p> <p>Background</p> <p>Chronic kidney disease (CKD) is a growing public health problem and end stage renal disease (ESRD) represents a large human and economic burden. It is important to identify patients at high risk of ESRD. In order to determine whether...
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | BMC Nephrology |
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| Online Access: | http://www.biomedcentral.com/1471-2369/13/139 |
| _version_ | 1818141142409019392 |
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| author | Bigé Naïke Lévy Pierre Callard Patrice Faintuch Jean-Manuel Chigot Valérie Jousselin Virginie Ronco Pierre Boffa Jean-Jacques |
| author_facet | Bigé Naïke Lévy Pierre Callard Patrice Faintuch Jean-Manuel Chigot Valérie Jousselin Virginie Ronco Pierre Boffa Jean-Jacques |
| author_sort | Bigé Naïke |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Chronic kidney disease (CKD) is a growing public health problem and end stage renal disease (ESRD) represents a large human and economic burden. It is important to identify patients at high risk of ESRD. In order to determine whether renal Doppler resistive index (RI) may discriminate those patients, we analyzed whether RI was associated with identified prognosis factors of CKD, in particular histological findings, and with renal outcome.</p> <p>Methods</p> <p>RI was measured in the 48 hours before renal biopsy in 58 CKD patients. Clinical and biological data were collected prospectively at inclusion. Arteriosclerosis, interstitial fibrosis and glomerulosclerosis were quantitatively assessed on renal biopsy in a blinded fashion. MDRD eGFR at 18 months was collected for 35 (60%) patients. Renal function decline was defined as a decrease in eGFR from baseline of at least 5 mL/min/ 1.73 m<sup>2</sup>/year or need for chronic renal replacement therapy. Pearson’s correlation, Mann–Whitney and Chi-square tests were used for analysis of quantitative and qualitative variables respectively. Kaplan Meier analysis was realized to determine renal survival according to RI value using the log-rank test. Multiple logistic regression was performed including variables with p < 0.20 in univariate analysis.</p> <p>Results</p> <p>Most patients had glomerulonephritis (82%). Median age was 46 years [21–87], eGFR 59 mL/min/ 1.73m<sup>2</sup> [5–130], percentage of interstitial fibrosis 10% [0–90], glomerulosclerosis 13% [0–96] and RI 0.63 [0.31-1.00]. RI increased with age (r = 0.435, p = 0.0063), pulse pressure (r = 0.303, p = 0.022), renal atrophy (r = −0.275, p = 0.038) and renal dysfunction (r = −0.402, p = 0.0018). Patients with arterial intima/media ratio ≥ 1 (p = 0.032), interstitial fibrosis > 20% (p = 0.014) and renal function decline (p = 0.0023) had higher RI. Patients with baseline RI ≥ 0.65 had a poorer renal outcome than those with baseline RI < 0.65 (p = 0.0005). In multiple logistic regression, RI≥0.65 was associated with accelerated renal function decline independently of baseline eGFR and proteinuria/creatininuria ratio (OR=13.04 [1.984-85.727], p = 0.0075). Sensitivity, specificity, predictive positive and predictive negative values of RI ≥ 0.65 for renal function decline at 18 months were respectively 77%, 86%, 71% and 82%.</p> <p>Conclusions</p> <p>Our results suggest that RI ≥ 0.65 is associated with severe interstitial fibrosis and arteriosclerosis and renal function decline. Thus, RI may contribute to identify patients at high risk of ESRD who may benefit from nephroprotective treatments.</p> |
| first_indexed | 2024-12-11T10:55:11Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-11T10:55:11Z |
| publishDate | 2012-10-01 |
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| series | BMC Nephrology |
| spelling | doaj.art-d27273dee24b49fd854912a02651d12f2022-12-22T01:10:08ZengBMCBMC Nephrology1471-23692012-10-0113113910.1186/1471-2369-13-139Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney diseaseBigé NaïkeLévy PierreCallard PatriceFaintuch Jean-ManuelChigot ValérieJousselin VirginieRonco PierreBoffa Jean-Jacques<p>Abstract</p> <p>Background</p> <p>Chronic kidney disease (CKD) is a growing public health problem and end stage renal disease (ESRD) represents a large human and economic burden. It is important to identify patients at high risk of ESRD. In order to determine whether renal Doppler resistive index (RI) may discriminate those patients, we analyzed whether RI was associated with identified prognosis factors of CKD, in particular histological findings, and with renal outcome.</p> <p>Methods</p> <p>RI was measured in the 48 hours before renal biopsy in 58 CKD patients. Clinical and biological data were collected prospectively at inclusion. Arteriosclerosis, interstitial fibrosis and glomerulosclerosis were quantitatively assessed on renal biopsy in a blinded fashion. MDRD eGFR at 18 months was collected for 35 (60%) patients. Renal function decline was defined as a decrease in eGFR from baseline of at least 5 mL/min/ 1.73 m<sup>2</sup>/year or need for chronic renal replacement therapy. Pearson’s correlation, Mann–Whitney and Chi-square tests were used for analysis of quantitative and qualitative variables respectively. Kaplan Meier analysis was realized to determine renal survival according to RI value using the log-rank test. Multiple logistic regression was performed including variables with p < 0.20 in univariate analysis.</p> <p>Results</p> <p>Most patients had glomerulonephritis (82%). Median age was 46 years [21–87], eGFR 59 mL/min/ 1.73m<sup>2</sup> [5–130], percentage of interstitial fibrosis 10% [0–90], glomerulosclerosis 13% [0–96] and RI 0.63 [0.31-1.00]. RI increased with age (r = 0.435, p = 0.0063), pulse pressure (r = 0.303, p = 0.022), renal atrophy (r = −0.275, p = 0.038) and renal dysfunction (r = −0.402, p = 0.0018). Patients with arterial intima/media ratio ≥ 1 (p = 0.032), interstitial fibrosis > 20% (p = 0.014) and renal function decline (p = 0.0023) had higher RI. Patients with baseline RI ≥ 0.65 had a poorer renal outcome than those with baseline RI < 0.65 (p = 0.0005). In multiple logistic regression, RI≥0.65 was associated with accelerated renal function decline independently of baseline eGFR and proteinuria/creatininuria ratio (OR=13.04 [1.984-85.727], p = 0.0075). Sensitivity, specificity, predictive positive and predictive negative values of RI ≥ 0.65 for renal function decline at 18 months were respectively 77%, 86%, 71% and 82%.</p> <p>Conclusions</p> <p>Our results suggest that RI ≥ 0.65 is associated with severe interstitial fibrosis and arteriosclerosis and renal function decline. Thus, RI may contribute to identify patients at high risk of ESRD who may benefit from nephroprotective treatments.</p>http://www.biomedcentral.com/1471-2369/13/139Chronic kidney diseaseArteriosclerosisFibrosisRenal doppler |
| spellingShingle | Bigé Naïke Lévy Pierre Callard Patrice Faintuch Jean-Manuel Chigot Valérie Jousselin Virginie Ronco Pierre Boffa Jean-Jacques Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease BMC Nephrology Chronic kidney disease Arteriosclerosis Fibrosis Renal doppler |
| title | Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease |
| title_full | Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease |
| title_fullStr | Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease |
| title_full_unstemmed | Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease |
| title_short | Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease |
| title_sort | renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease |
| topic | Chronic kidney disease Arteriosclerosis Fibrosis Renal doppler |
| url | http://www.biomedcentral.com/1471-2369/13/139 |
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