Towards Understanding the Function of Aegerolysins
Aegerolysins are remarkable proteins. They are distributed over the tree of life, being relatively widespread in bacteria and fungi, but also present in some insects, plants, protozoa, and viruses. Despite their abundance in cells of certain developmental stages and their presence in secretomes, onl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/14/9/629 |
| _version_ | 1827656293821710336 |
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| author | Nada Kraševec Matej Skočaj |
| author_facet | Nada Kraševec Matej Skočaj |
| author_sort | Nada Kraševec |
| collection | DOAJ |
| description | Aegerolysins are remarkable proteins. They are distributed over the tree of life, being relatively widespread in bacteria and fungi, but also present in some insects, plants, protozoa, and viruses. Despite their abundance in cells of certain developmental stages and their presence in secretomes, only a few aegerolysins have been studied in detail. Their function, in particular, is intriguing. Here, we summarize previously published findings on the distribution, molecular interactions, and function of these versatile aegerolysins. They have very diverse protein sequences but a common fold. The machine learning approach of the AlphaFold2 algorithm, which incorporates physical and biological knowledge of protein structures and multisequence alignments, provides us new insights into the aegerolysins and their pore-forming partners, complemented by additional genomic support. We hypothesize that aegerolysins are involved in the mechanisms of competitive exclusion in the niche. |
| first_indexed | 2024-03-09T22:19:37Z |
| format | Article |
| id | doaj.art-d2734e3bff8e41fbb6c96ff4fdb19591 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T22:19:37Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-d2734e3bff8e41fbb6c96ff4fdb195912023-11-23T19:17:01ZengMDPI AGToxins2072-66512022-09-0114962910.3390/toxins14090629Towards Understanding the Function of AegerolysinsNada Kraševec0Matej Skočaj1Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, SI-1000 Ljubljana, SloveniaDepartment of Biology, Biotechnical Faculty, University of Ljubljana, SI-1000 Ljubljana, SloveniaAegerolysins are remarkable proteins. They are distributed over the tree of life, being relatively widespread in bacteria and fungi, but also present in some insects, plants, protozoa, and viruses. Despite their abundance in cells of certain developmental stages and their presence in secretomes, only a few aegerolysins have been studied in detail. Their function, in particular, is intriguing. Here, we summarize previously published findings on the distribution, molecular interactions, and function of these versatile aegerolysins. They have very diverse protein sequences but a common fold. The machine learning approach of the AlphaFold2 algorithm, which incorporates physical and biological knowledge of protein structures and multisequence alignments, provides us new insights into the aegerolysins and their pore-forming partners, complemented by additional genomic support. We hypothesize that aegerolysins are involved in the mechanisms of competitive exclusion in the niche.https://www.mdpi.com/2072-6651/14/9/629aegerolysinsAlphaFold structure modelingbacteriacompetitive exclusionfungiinsecticidal |
| spellingShingle | Nada Kraševec Matej Skočaj Towards Understanding the Function of Aegerolysins Toxins aegerolysins AlphaFold structure modeling bacteria competitive exclusion fungi insecticidal |
| title | Towards Understanding the Function of Aegerolysins |
| title_full | Towards Understanding the Function of Aegerolysins |
| title_fullStr | Towards Understanding the Function of Aegerolysins |
| title_full_unstemmed | Towards Understanding the Function of Aegerolysins |
| title_short | Towards Understanding the Function of Aegerolysins |
| title_sort | towards understanding the function of aegerolysins |
| topic | aegerolysins AlphaFold structure modeling bacteria competitive exclusion fungi insecticidal |
| url | https://www.mdpi.com/2072-6651/14/9/629 |
| work_keys_str_mv | AT nadakrasevec towardsunderstandingthefunctionofaegerolysins AT matejskocaj towardsunderstandingthefunctionofaegerolysins |