Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, to death. Abnormalities at the neuromuscular junction (NMJ) have been reported in SMA, including neurofi...

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Main Authors: Marina Boido, Elena De Amicis, Valeria Valsecchi, Marco Trevisan, Ugo Ala, Markus A. Ruegg, Stefan Hettwer, Alessandro Vercelli
格式: 文件
语言:English
出版: Frontiers Media S.A. 2018-01-01
丛编:Frontiers in Cellular Neuroscience
主题:
motor neuron disease
neuromuscular junctions
muscle
motor performance
innervation
在线阅读:http://journal.frontiersin.org/article/10.3389/fncel.2018.00017/full

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http://journal.frontiersin.org/article/10.3389/fncel.2018.00017/full

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