Endothelial Protein C Receptor and Its Impact on Rheumatic Disease
Endothelial Protein C Receptor (EPCR) is a key regulator of the activated protein C anti-coagulation pathway due to its role in the binding and activation of this protein. EPCR also binds to other ligands such as Factor VII and X, γδ T-cells, plasmodium falciparum erythrocyte membrane protein 1, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/2030 |
| _version_ | 1797212390861832192 |
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| author | Zachary Daniel O’Hehir Tom Lynch Sean O’Neill Lyn March Meilang Xue |
| author_facet | Zachary Daniel O’Hehir Tom Lynch Sean O’Neill Lyn March Meilang Xue |
| author_sort | Zachary Daniel O’Hehir |
| collection | DOAJ |
| description | Endothelial Protein C Receptor (EPCR) is a key regulator of the activated protein C anti-coagulation pathway due to its role in the binding and activation of this protein. EPCR also binds to other ligands such as Factor VII and X, γδ T-cells, plasmodium falciparum erythrocyte membrane protein 1, and Secretory group V Phospholipases A2, facilitating ligand-specific functions. The functions of EPCR can also be regulated by soluble (s)EPCR that competes for the binding sites of membrane-bound (m)EPCR. sEPCR is created when mEPCR is shed from the cell surface. The propensity of shedding alters depending on the genetic haplotype of the <i>EPCR</i> gene that an individual may possess. EPCR plays an active role in normal homeostasis, anti-coagulation pathways, inflammation, and cell stemness. Due to these properties, EPCR is considered a potential effector/mediator of inflammatory diseases. Rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are autoimmune/inflammatory conditions that are associated with elevated EPCR levels and disease activity, potentially driven by EPCR. This review highlights the functions of EPCR and its contribution to rheumatic diseases. |
| first_indexed | 2024-04-24T10:41:38Z |
| format | Article |
| id | doaj.art-d2745e8dbe994114bd72b2dcb89a43d7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:41:38Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-d2745e8dbe994114bd72b2dcb89a43d72024-04-12T13:21:20ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01137203010.3390/jcm13072030Endothelial Protein C Receptor and Its Impact on Rheumatic DiseaseZachary Daniel O’Hehir0Tom Lynch1Sean O’Neill2Lyn March3Meilang Xue4Sutton Arthritis Research Laboratory, Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney at Royal North Shore Hospital, Sydney, NSW 2065, AustraliaThe Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Institute of Bone and Joint Research, Kolling Institute, Faculty of Medicine and Health, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, AustraliaDepartment of Rheumatology, Royal North Shore Hospital, Syndey, NSW 2065, AustraliaThe Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Institute of Bone and Joint Research, Kolling Institute, Faculty of Medicine and Health, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, AustraliaSutton Arthritis Research Laboratory, Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney at Royal North Shore Hospital, Sydney, NSW 2065, AustraliaEndothelial Protein C Receptor (EPCR) is a key regulator of the activated protein C anti-coagulation pathway due to its role in the binding and activation of this protein. EPCR also binds to other ligands such as Factor VII and X, γδ T-cells, plasmodium falciparum erythrocyte membrane protein 1, and Secretory group V Phospholipases A2, facilitating ligand-specific functions. The functions of EPCR can also be regulated by soluble (s)EPCR that competes for the binding sites of membrane-bound (m)EPCR. sEPCR is created when mEPCR is shed from the cell surface. The propensity of shedding alters depending on the genetic haplotype of the <i>EPCR</i> gene that an individual may possess. EPCR plays an active role in normal homeostasis, anti-coagulation pathways, inflammation, and cell stemness. Due to these properties, EPCR is considered a potential effector/mediator of inflammatory diseases. Rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are autoimmune/inflammatory conditions that are associated with elevated EPCR levels and disease activity, potentially driven by EPCR. This review highlights the functions of EPCR and its contribution to rheumatic diseases.https://www.mdpi.com/2077-0383/13/7/2030endothelial protein C receptoractivated protein Crheumatoid arthritissystemic lupus erythematosus |
| spellingShingle | Zachary Daniel O’Hehir Tom Lynch Sean O’Neill Lyn March Meilang Xue Endothelial Protein C Receptor and Its Impact on Rheumatic Disease Journal of Clinical Medicine endothelial protein C receptor activated protein C rheumatoid arthritis systemic lupus erythematosus |
| title | Endothelial Protein C Receptor and Its Impact on Rheumatic Disease |
| title_full | Endothelial Protein C Receptor and Its Impact on Rheumatic Disease |
| title_fullStr | Endothelial Protein C Receptor and Its Impact on Rheumatic Disease |
| title_full_unstemmed | Endothelial Protein C Receptor and Its Impact on Rheumatic Disease |
| title_short | Endothelial Protein C Receptor and Its Impact on Rheumatic Disease |
| title_sort | endothelial protein c receptor and its impact on rheumatic disease |
| topic | endothelial protein C receptor activated protein C rheumatoid arthritis systemic lupus erythematosus |
| url | https://www.mdpi.com/2077-0383/13/7/2030 |
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