Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial
Purpose: To evaluate the safety of local bevacizumab and its effect on recurrence of primary pterygium excision. Methods: This randomized, placebo-controlled clinical trial was conducted on 44 eyes of 44 patients randomized to Group 1 (bevacizumab) and Group 2 (balanced salt solution). Group 1 unde...
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| Format: | Article |
| Language: | English |
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Knowledge E
2014-01-01
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| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=1;spage=22;epage=30;aulast=Razeghinejad |
| _version_ | 1811323657285271552 |
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| author | Mohammad-Reza Razeghinejad Mohammad Banifatemi |
| author_facet | Mohammad-Reza Razeghinejad Mohammad Banifatemi |
| author_sort | Mohammad-Reza Razeghinejad |
| collection | DOAJ |
| description | Purpose: To evaluate the safety of local bevacizumab and its effect on recurrence of primary pterygium excision.
Methods: This randomized, placebo-controlled clinical trial was conducted on 44 eyes of 44 patients randomized to Group 1 (bevacizumab) and Group 2 (balanced salt solution). Group 1 underwent pterygium excision with a rotational conjunctival flap and received a total of 7.5 mg subconjunctival bevacizumab (5 mg/0.2 mL on the day of surgery and 2.5 mg/0.1 mL on the fourth day after surgery). Group 2 received balanced salt solution in the same manner. Recurrence, defined as any fibrovascular tissue crossing the limbus, and the number of patients with >1.5 mm fibrovascular overgrowth on the cornea were compared between the study groups.
Results: There was no statistically significant difference between the study groups in terms of demographics, pterygium size, daily sun exposure, preoperative visual acuity, keratomeric readings, corneal astigmatism, or IOP (P>0.05). Three and four patients in each group at the three- and six-month visits, respectively, had more than 1.5 mm fibrovascular tissue overgrowth on the cornea (P=1 and 0.62, respectively). At the three-month visit, 3 patients in Group 1 versus 7 patients in Group 2 (P=0.13), and at the six-month visit 4 patients in Group 1 versus 8 patients in Group 2 (P=0.17) had fibrovascular tissue crossing the limbus. Patients in Group 1 experienced a statistically significant rise in IOP at the one-week visit (P=0.007).
Conclusion: Bevacizumab had no significant effect on the recurrence rate of pterygium. Although the frequency of fibrovascular tissue crossing the limbus in the bevacizumab group was half that of the BSS group, the difference failed to reach a statistically significant level. |
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| format | Article |
| id | doaj.art-d276940492e64edab080e64269f650cc |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-13T13:59:04Z |
| publishDate | 2014-01-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-d276940492e64edab080e64269f650cc2022-12-22T02:44:06ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-01912230Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical TrialMohammad-Reza RazeghinejadMohammad BanifatemiPurpose: To evaluate the safety of local bevacizumab and its effect on recurrence of primary pterygium excision. Methods: This randomized, placebo-controlled clinical trial was conducted on 44 eyes of 44 patients randomized to Group 1 (bevacizumab) and Group 2 (balanced salt solution). Group 1 underwent pterygium excision with a rotational conjunctival flap and received a total of 7.5 mg subconjunctival bevacizumab (5 mg/0.2 mL on the day of surgery and 2.5 mg/0.1 mL on the fourth day after surgery). Group 2 received balanced salt solution in the same manner. Recurrence, defined as any fibrovascular tissue crossing the limbus, and the number of patients with >1.5 mm fibrovascular overgrowth on the cornea were compared between the study groups. Results: There was no statistically significant difference between the study groups in terms of demographics, pterygium size, daily sun exposure, preoperative visual acuity, keratomeric readings, corneal astigmatism, or IOP (P>0.05). Three and four patients in each group at the three- and six-month visits, respectively, had more than 1.5 mm fibrovascular tissue overgrowth on the cornea (P=1 and 0.62, respectively). At the three-month visit, 3 patients in Group 1 versus 7 patients in Group 2 (P=0.13), and at the six-month visit 4 patients in Group 1 versus 8 patients in Group 2 (P=0.17) had fibrovascular tissue crossing the limbus. Patients in Group 1 experienced a statistically significant rise in IOP at the one-week visit (P=0.007). Conclusion: Bevacizumab had no significant effect on the recurrence rate of pterygium. Although the frequency of fibrovascular tissue crossing the limbus in the bevacizumab group was half that of the BSS group, the difference failed to reach a statistically significant level.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=1;spage=22;epage=30;aulast=RazeghinejadAngiogenesis; Bevacizumab; Pterygium; Pterygium Recurrence |
| spellingShingle | Mohammad-Reza Razeghinejad Mohammad Banifatemi Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial Journal of Ophthalmic & Vision Research Angiogenesis; Bevacizumab; Pterygium; Pterygium Recurrence |
| title | Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial |
| title_full | Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial |
| title_fullStr | Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial |
| title_full_unstemmed | Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial |
| title_short | Subconjunctival Bevacizumab for Primary Pterygium Excision; a Randomized Clinical Trial |
| title_sort | subconjunctival bevacizumab for primary pterygium excision a randomized clinical trial |
| topic | Angiogenesis; Bevacizumab; Pterygium; Pterygium Recurrence |
| url | http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=1;spage=22;epage=30;aulast=Razeghinejad |
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