Dosimetric characterization of an intensity-modulated X-ray brachytherapy system
Purpose: An intensity-modulated X-ray brachytherapy system is being developed for various clinical applications. This new system makes it possible for clinical staff to control energy as well as dose rate for different tumor sites according to their sizes and radiobiological characteristics. Materia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Medical Physics |
| Subjects: | |
| Online Access: | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2018;volume=43;issue=4;spage=247;epage=254;aulast=Lee |
| _version_ | 1818850746605502464 |
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| author | Sung-Woo Lee Evgeny Sozontov Emil Strumban Fang-Fang Yin |
| author_facet | Sung-Woo Lee Evgeny Sozontov Emil Strumban Fang-Fang Yin |
| author_sort | Sung-Woo Lee |
| collection | DOAJ |
| description | Purpose: An intensity-modulated X-ray brachytherapy system is being developed for various clinical applications. This new system makes it possible for clinical staff to control energy as well as dose rate for different tumor sites according to their sizes and radiobiological characteristics. Materials and Methods: This system is mainly composed of an X-ray tube, guide tube collimation, and secondary (pseudo) target. Due to its configuration, convenient modulations of fluorescent X-ray energy and intensity are possible. To observe applicability of this novel system for various primary and secondary target combinations, Monte Carlo simulation using MCNP5 was performed, and air measurements were done. As a primary and pseudo-target combination, silver–molybdenum (Ag-Mo), tungsten–neodymium (W-Nd), and tungsten–erbium (W-Er) were used for the calculation for dose profile. Specifically, a dose distribution was calculated around each of these target combinations. Dose distributions as a function of target angles were also calculated. The Ag-Mo combination was analyzed for Cartesian coordinates of xy, xz, and yz planes of the pseudo-target to observe dose distribution as a function of the angle of secondary target. Results: The results showed that radial dose fall-off of Ag-Mo was greater than commercially available brachytherapy sources (103Pd and 125I) due to its low characteristic X-ray energy. Conclusions: Dose distribution variance should be considered in beam modulation for clinical application. Dynamic movement of the pseudo-target is feasible and remains as a subject for future research. |
| first_indexed | 2024-12-19T06:54:02Z |
| format | Article |
| id | doaj.art-d278c9f7eaca435f93eddf591b10e87e |
| institution | Directory Open Access Journal |
| issn | 0971-6203 1998-3913 |
| language | English |
| last_indexed | 2024-12-19T06:54:02Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Physics |
| spelling | doaj.art-d278c9f7eaca435f93eddf591b10e87e2022-12-21T20:31:36ZengWolters Kluwer Medknow PublicationsJournal of Medical Physics0971-62031998-39132018-01-0143424725410.4103/jmp.JMP_52_18Dosimetric characterization of an intensity-modulated X-ray brachytherapy systemSung-Woo LeeEvgeny SozontovEmil StrumbanFang-Fang YinPurpose: An intensity-modulated X-ray brachytherapy system is being developed for various clinical applications. This new system makes it possible for clinical staff to control energy as well as dose rate for different tumor sites according to their sizes and radiobiological characteristics. Materials and Methods: This system is mainly composed of an X-ray tube, guide tube collimation, and secondary (pseudo) target. Due to its configuration, convenient modulations of fluorescent X-ray energy and intensity are possible. To observe applicability of this novel system for various primary and secondary target combinations, Monte Carlo simulation using MCNP5 was performed, and air measurements were done. As a primary and pseudo-target combination, silver–molybdenum (Ag-Mo), tungsten–neodymium (W-Nd), and tungsten–erbium (W-Er) were used for the calculation for dose profile. Specifically, a dose distribution was calculated around each of these target combinations. Dose distributions as a function of target angles were also calculated. The Ag-Mo combination was analyzed for Cartesian coordinates of xy, xz, and yz planes of the pseudo-target to observe dose distribution as a function of the angle of secondary target. Results: The results showed that radial dose fall-off of Ag-Mo was greater than commercially available brachytherapy sources (103Pd and 125I) due to its low characteristic X-ray energy. Conclusions: Dose distribution variance should be considered in beam modulation for clinical application. Dynamic movement of the pseudo-target is feasible and remains as a subject for future research.http://www.jmp.org.in/article.asp?issn=0971-6203;year=2018;volume=43;issue=4;spage=247;epage=254;aulast=LeeBrachytherapydosimetryintensity modulatedX-ray |
| spellingShingle | Sung-Woo Lee Evgeny Sozontov Emil Strumban Fang-Fang Yin Dosimetric characterization of an intensity-modulated X-ray brachytherapy system Journal of Medical Physics Brachytherapy dosimetry intensity modulated X-ray |
| title | Dosimetric characterization of an intensity-modulated X-ray brachytherapy system |
| title_full | Dosimetric characterization of an intensity-modulated X-ray brachytherapy system |
| title_fullStr | Dosimetric characterization of an intensity-modulated X-ray brachytherapy system |
| title_full_unstemmed | Dosimetric characterization of an intensity-modulated X-ray brachytherapy system |
| title_short | Dosimetric characterization of an intensity-modulated X-ray brachytherapy system |
| title_sort | dosimetric characterization of an intensity modulated x ray brachytherapy system |
| topic | Brachytherapy dosimetry intensity modulated X-ray |
| url | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2018;volume=43;issue=4;spage=247;epage=254;aulast=Lee |
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