P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?
Objective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2015-11-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930661/view |
| _version_ | 1828201619721814016 |
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| author | Lorenzo Ghiadoni* Rosa Maria Bruno Francesco Regoli Giuseppe Penno Stefano Taddei |
| author_facet | Lorenzo Ghiadoni* Rosa Maria Bruno Francesco Regoli Giuseppe Penno Stefano Taddei |
| author_sort | Lorenzo Ghiadoni* |
| collection | DOAJ |
| description | Objective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing also lower (forearm, L) and upper (arm, U) cuff occlusion.
Methods: In 17 young healthy subjects (9 males, age 29±4 years) FMD (Cardiovascular Suite, Quipu s.r.l., Pisa, Italy). and RHI (EndoPAT 2000, Itamar Medical, Israel) were measured simultaneously in two separate occasions using 5 minutes of L- or U-ischemia. Baseline and Hyperemic Shear rate (SR) were also computed.
Results: L-FMD (7.32±4.87%) and L-RHI (0,61±0.29%) were significantly lower (p<0.05 and p<0.01, respectively) as compared to U-FMD (10.48±5.67%) and U-RHI (0.86±0.23%). L-RHI and U-RHI tended to be related (r=0.49; p=0.06), while L-FMD and U-FMD were not (r=0.39; p=0.12),
L-FMD was significantly related to L-SR (r=0.62; p<0.01), but not to L-RHI (r=0.17; p=0.54). L-RHI was not significantly correlated with L-SR (r=0.24; p=0,38). U-RHI was related to U-FMD (r=0.50; p<0.05) and to U-SR (r=0.50, p<0.04). In multiple regression analysis (full model: r2=0.23) U-FMD but not U-SR was associated with U-RHI (r2=0.20; p=0.05).
Conclusions: In healthy subjects, the assessment of FMD and RHI with lower and upper cuff occlusion is not equivalent. L-FMD, but not U-FMD is related to SR increase, thus possibly representing a better marker for conduit artery endothelial function. U-RHI and U-FMD possibly provide similar information on vascular reactivity. Caution is deemed in interpreting studies conducted with different methodologies. |
| first_indexed | 2024-04-12T11:32:30Z |
| format | Article |
| id | doaj.art-d278d55df27644388667a0b009af700e |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-12T11:32:30Z |
| publishDate | 2015-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-d278d55df27644388667a0b009af700e2022-12-22T03:34:57ZengBMCArtery Research1876-44012015-11-011210.1016/j.artres.2015.10.318P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?Lorenzo Ghiadoni*Rosa Maria BrunoFrancesco RegoliGiuseppe PennoStefano TaddeiObjective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing also lower (forearm, L) and upper (arm, U) cuff occlusion. Methods: In 17 young healthy subjects (9 males, age 29±4 years) FMD (Cardiovascular Suite, Quipu s.r.l., Pisa, Italy). and RHI (EndoPAT 2000, Itamar Medical, Israel) were measured simultaneously in two separate occasions using 5 minutes of L- or U-ischemia. Baseline and Hyperemic Shear rate (SR) were also computed. Results: L-FMD (7.32±4.87%) and L-RHI (0,61±0.29%) were significantly lower (p<0.05 and p<0.01, respectively) as compared to U-FMD (10.48±5.67%) and U-RHI (0.86±0.23%). L-RHI and U-RHI tended to be related (r=0.49; p=0.06), while L-FMD and U-FMD were not (r=0.39; p=0.12), L-FMD was significantly related to L-SR (r=0.62; p<0.01), but not to L-RHI (r=0.17; p=0.54). L-RHI was not significantly correlated with L-SR (r=0.24; p=0,38). U-RHI was related to U-FMD (r=0.50; p<0.05) and to U-SR (r=0.50, p<0.04). In multiple regression analysis (full model: r2=0.23) U-FMD but not U-SR was associated with U-RHI (r2=0.20; p=0.05). Conclusions: In healthy subjects, the assessment of FMD and RHI with lower and upper cuff occlusion is not equivalent. L-FMD, but not U-FMD is related to SR increase, thus possibly representing a better marker for conduit artery endothelial function. U-RHI and U-FMD possibly provide similar information on vascular reactivity. Caution is deemed in interpreting studies conducted with different methodologies.https://www.atlantis-press.com/article/125930661/view |
| spellingShingle | Lorenzo Ghiadoni* Rosa Maria Bruno Francesco Regoli Giuseppe Penno Stefano Taddei P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? Artery Research |
| title | P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? |
| title_full | P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? |
| title_fullStr | P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? |
| title_full_unstemmed | P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? |
| title_short | P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? |
| title_sort | p7 15 reactive hyperemia index and flow mediated dilation with upper and lower arm cuff occlusion are they measuring the same |
| url | https://www.atlantis-press.com/article/125930661/view |
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