Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict replication of certain viruses. While the antiviral activity of MARCH8 has been intensively studied, less is known regarding virus inhibition by MARCH1. Isoforms 1 and 2...

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Bibliographic Details
Main Authors: Fernando Villalón-Letelier, Rubaiyea Farrukee, Sarah L. Londrigan, Andrew G. Brooks, Patrick C. Reading
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Viruses
Subjects:
influenza A virus
E3 ubiquitin ligase
ubiquitination
virus restriction
Online Access:https://www.mdpi.com/1999-4915/14/11/2549

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