Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study
ABSTRACTBackground: Acute kidney injury (AKI) is a common complication associated with cardiac surgery with cardiopulmonary bypass (CPB) with a deleterious effect on morbidity and mortality. The current study aimed to determine the efficacy of preoperative creatine kinase-MB (CK-MB) level for the pr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Egyptian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/11101849.2021.1883811 |
| _version_ | 1797683767382376448 |
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| author | Mohammad Gomaa Salwa Shaarawy Shahira Almetainy Reham Abo Elwafa |
| author_facet | Mohammad Gomaa Salwa Shaarawy Shahira Almetainy Reham Abo Elwafa |
| author_sort | Mohammad Gomaa |
| collection | DOAJ |
| description | ABSTRACTBackground: Acute kidney injury (AKI) is a common complication associated with cardiac surgery with cardiopulmonary bypass (CPB) with a deleterious effect on morbidity and mortality. The current study aimed to determine the efficacy of preoperative creatine kinase-MB (CK-MB) level for the prediction of occurrence and severity of AKI.Settings and Design: This study was a prospective cross-sectional observational study.Methods: The study was carried out on 74 pediatric patients aged less than 18 years scheduled for elective congenital cardiac surgery using CPB. The prevalence of AKI within 72 hours was defined according to the three-stage Acute Kidney Injury Network (AKIN) criteria. Logistic regression analysis was done and adjusted odds ratio (OR) and confidence intervals at 95% (95% CI) were calculated.Results: AKI had developed in 25 patients (33.78%) by the second postoperative day. Patients who developed AKI had higher mean levels of preoperative CK-MB compared with patients without AKI (P = 0.002). Lower mean age, longer duration of surgery, bypass time, and cross-clamp time were independently associated with AKI (p < 0.015, 0.001, 0.001and 0.001, respectively). Patients who developed AKI had a longer duration of mechanical ventilation (MV) (OR 1.3, 95% CI 1.147–1.691) so; they required longer intensive care unit (ICU) stay.Conclusion: CK-MB can be a useful biomarker for detecting early AKI after congenital cardiac surgery and predicting adverse clinical outcomes. |
| first_indexed | 2024-03-12T00:20:36Z |
| format | Article |
| id | doaj.art-d27aff1ce77541109334cebcfca49a83 |
| institution | Directory Open Access Journal |
| issn | 1110-1849 |
| language | English |
| last_indexed | 2024-03-12T00:20:36Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Egyptian Journal of Anaesthesia |
| spelling | doaj.art-d27aff1ce77541109334cebcfca49a832023-09-15T13:38:33ZengTaylor & Francis GroupEgyptian Journal of Anaesthesia1110-18492021-01-01371576110.1080/11101849.2021.1883811Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective studyMohammad Gomaa0Salwa Shaarawy1Shahira Almetainy2Reham Abo Elwafa3Anesthesia and Surgical Intensive Care, Alexandria Faculty of Medicine, Alexandria, EgyptAnesthesia and Surgical Intensive Care, Alexandria Faculty of Medicine, Alexandria, EgyptAnesthesia and Surgical Intensive Care, Alexandria Faculty of Medicine, Alexandria, EgyptClinical Pathology, Alexandria Faculty of Medicine, Alexandria, EgyptABSTRACTBackground: Acute kidney injury (AKI) is a common complication associated with cardiac surgery with cardiopulmonary bypass (CPB) with a deleterious effect on morbidity and mortality. The current study aimed to determine the efficacy of preoperative creatine kinase-MB (CK-MB) level for the prediction of occurrence and severity of AKI.Settings and Design: This study was a prospective cross-sectional observational study.Methods: The study was carried out on 74 pediatric patients aged less than 18 years scheduled for elective congenital cardiac surgery using CPB. The prevalence of AKI within 72 hours was defined according to the three-stage Acute Kidney Injury Network (AKIN) criteria. Logistic regression analysis was done and adjusted odds ratio (OR) and confidence intervals at 95% (95% CI) were calculated.Results: AKI had developed in 25 patients (33.78%) by the second postoperative day. Patients who developed AKI had higher mean levels of preoperative CK-MB compared with patients without AKI (P = 0.002). Lower mean age, longer duration of surgery, bypass time, and cross-clamp time were independently associated with AKI (p < 0.015, 0.001, 0.001and 0.001, respectively). Patients who developed AKI had a longer duration of mechanical ventilation (MV) (OR 1.3, 95% CI 1.147–1.691) so; they required longer intensive care unit (ICU) stay.Conclusion: CK-MB can be a useful biomarker for detecting early AKI after congenital cardiac surgery and predicting adverse clinical outcomes.https://www.tandfonline.com/doi/10.1080/11101849.2021.1883811Congenital cardiac surgeryacute kidney injuryCK-MBNGAL |
| spellingShingle | Mohammad Gomaa Salwa Shaarawy Shahira Almetainy Reham Abo Elwafa Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study Egyptian Journal of Anaesthesia Congenital cardiac surgery acute kidney injury CK-MB NGAL |
| title | Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study |
| title_full | Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study |
| title_fullStr | Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study |
| title_full_unstemmed | Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study |
| title_short | Value of Preoperative Creatine Kinase-MB for Prediction of Acute Kidney Injury in Congenital Cardiac Surgery Using Cardiopulmonary Bypass: a prospective study |
| title_sort | value of preoperative creatine kinase mb for prediction of acute kidney injury in congenital cardiac surgery using cardiopulmonary bypass a prospective study |
| topic | Congenital cardiac surgery acute kidney injury CK-MB NGAL |
| url | https://www.tandfonline.com/doi/10.1080/11101849.2021.1883811 |
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