THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH
Osteoimmunology is field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate the skeleton in health and disease are T lymphocytes. T cells secrete inflammatory/osteoclastogenic cytokines such as RANKL, TNF an...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00057/full |
| _version_ | 1828239062701441024 |
|---|---|
| author | Roberto ePacifici |
| author_facet | Roberto ePacifici |
| author_sort | Roberto ePacifici |
| collection | DOAJ |
| description | Osteoimmunology is field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate the skeleton in health and disease are T lymphocytes. T cells secrete inflammatory/osteoclastogenic cytokines such as RANKL, TNF and IL-17, as well as factors that stimulate bone formation, including Wnt ligands. In addition, T cells regulate the differentiation and life span of stromal cells via CD40L and other costimulatory molecules expressed on their surface. Consensus exists that parathyroid hormone (PTH) induces bone loss by increasing the production of RANKL by osteocytes and osteoblast. However, new evidence suggests that PTH expands Th17 cells and increases IL-17 levels in mice and humans. Studies in the mouse of further shown that Th17 cell produced IL-17 acts as an upstream cytokine that increases the sensitivity of osteoblasts and osteocytes to PTH. As a result, PTH stimulates osteocytic and osteoblastic release of RANKL/. Therefore, PTH cause bone loss only in the presence of IL-17 signaling. This article reviews the evidence that the effects of PTH are mediated not only by osteoblasts and osteocytes, but also T cells and IL-17. |
| first_indexed | 2024-04-12T21:16:27Z |
| format | Article |
| id | doaj.art-d27c17ed98e542d1a5bf3ac23e981bf6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T21:16:27Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d27c17ed98e542d1a5bf3ac23e981bf62022-12-22T03:16:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-02-01710.3389/fimmu.2016.00057175778THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTHRoberto ePacifici0Emory UniversityOsteoimmunology is field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate the skeleton in health and disease are T lymphocytes. T cells secrete inflammatory/osteoclastogenic cytokines such as RANKL, TNF and IL-17, as well as factors that stimulate bone formation, including Wnt ligands. In addition, T cells regulate the differentiation and life span of stromal cells via CD40L and other costimulatory molecules expressed on their surface. Consensus exists that parathyroid hormone (PTH) induces bone loss by increasing the production of RANKL by osteocytes and osteoblast. However, new evidence suggests that PTH expands Th17 cells and increases IL-17 levels in mice and humans. Studies in the mouse of further shown that Th17 cell produced IL-17 acts as an upstream cytokine that increases the sensitivity of osteoblasts and osteocytes to PTH. As a result, PTH stimulates osteocytic and osteoblastic release of RANKL/. Therefore, PTH cause bone loss only in the presence of IL-17 signaling. This article reviews the evidence that the effects of PTH are mediated not only by osteoblasts and osteocytes, but also T cells and IL-17.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00057/fullOsteoblastsOsteocytesT cellsBoneIL-17PTH |
| spellingShingle | Roberto ePacifici THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH Frontiers in Immunology Osteoblasts Osteocytes T cells Bone IL-17 PTH |
| title | THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH |
| title_full | THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH |
| title_fullStr | THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH |
| title_full_unstemmed | THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH |
| title_short | THE ROLE OF IL-17 AND TH17 CELLS IN THE BONE CATABOLIC ACTIVITY OF PTH |
| title_sort | role of il 17 and th17 cells in the bone catabolic activity of pth |
| topic | Osteoblasts Osteocytes T cells Bone IL-17 PTH |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00057/full |
| work_keys_str_mv | AT robertoepacifici theroleofil17andth17cellsinthebonecatabolicactivityofpth AT robertoepacifici roleofil17andth17cellsinthebonecatabolicactivityofpth |