Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury
Facilitating functional recovery following brain injury is a key goal of neurorehabilitation. Direct, objective measures of changes in the brain are critical to understanding how and when meaningful changes occur, however, assessing neuroplasticity using brain based results remains a significant cha...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584401731592X |
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| author | S. Porter I.J. Torres W. Panenka Z. Rajwani D. Fawcett A. Hyder N. Virji-Babul |
| author_facet | S. Porter I.J. Torres W. Panenka Z. Rajwani D. Fawcett A. Hyder N. Virji-Babul |
| author_sort | S. Porter |
| collection | DOAJ |
| description | Facilitating functional recovery following brain injury is a key goal of neurorehabilitation. Direct, objective measures of changes in the brain are critical to understanding how and when meaningful changes occur, however, assessing neuroplasticity using brain based results remains a significant challenge. Little is known about the underlying changes in functional brain networks that correlate with cognitive outcomes in traumatic brain injury (TBI). The purpose of this pilot study was to assess the feasibility of an intensive three month cognitive intervention program in individuals with chronic TBI and to evaluate the effects of this intervention on brain-behavioral relationships. We used tools from graph theory to evaluate changes in global and local brain network features prior to and following cognitive intervention. Network metrics were calculated from resting state electroencephalographic (EEG) recordings from 10 adult participants with mild to severe brain injury and 11 age and gender matched healthy controls. Local graph metrics showed hyper-connectivity in the right inferior frontal gyrus and hypo-connectivity in the left inferior frontal gyrus in the TBI group at baseline in comparison with the control group. Following the intervention, there was a statistically significant increase in the composite cognitive score in the TBI participants and a statistically significant decrease in functional connectivity in the right inferior frontal gyrus. In addition, there was evidence of changes in the brain-behavior relationships following intervention. The results from this pilot study provide preliminary evidence for functional network reorganization that parallels cognitive improvements after cognitive rehabilitation in individuals with chronic TBI. |
| first_indexed | 2024-04-13T18:25:10Z |
| format | Article |
| id | doaj.art-d27cf93c702f4ac3a975d7a53719abee |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-13T18:25:10Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d27cf93c702f4ac3a975d7a53719abee2022-12-22T02:35:16ZengElsevierHeliyon2405-84402017-08-013810.1016/j.heliyon.2017.e00373Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injuryS. Porter0I.J. Torres1W. Panenka2Z. Rajwani3D. Fawcett4A. Hyder5N. Virji-Babul6Graduate Program in Rehabilitation Sciences, University of British Columbia, CanadaDepartment of Psychiatry, University of British ColumbiaDepartment of Psychiatry, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry, University of British ColumbiaGraduate Program in Neuroscience, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health, University of British ColumbiaFacilitating functional recovery following brain injury is a key goal of neurorehabilitation. Direct, objective measures of changes in the brain are critical to understanding how and when meaningful changes occur, however, assessing neuroplasticity using brain based results remains a significant challenge. Little is known about the underlying changes in functional brain networks that correlate with cognitive outcomes in traumatic brain injury (TBI). The purpose of this pilot study was to assess the feasibility of an intensive three month cognitive intervention program in individuals with chronic TBI and to evaluate the effects of this intervention on brain-behavioral relationships. We used tools from graph theory to evaluate changes in global and local brain network features prior to and following cognitive intervention. Network metrics were calculated from resting state electroencephalographic (EEG) recordings from 10 adult participants with mild to severe brain injury and 11 age and gender matched healthy controls. Local graph metrics showed hyper-connectivity in the right inferior frontal gyrus and hypo-connectivity in the left inferior frontal gyrus in the TBI group at baseline in comparison with the control group. Following the intervention, there was a statistically significant increase in the composite cognitive score in the TBI participants and a statistically significant decrease in functional connectivity in the right inferior frontal gyrus. In addition, there was evidence of changes in the brain-behavior relationships following intervention. The results from this pilot study provide preliminary evidence for functional network reorganization that parallels cognitive improvements after cognitive rehabilitation in individuals with chronic TBI.http://www.sciencedirect.com/science/article/pii/S240584401731592XNeurologyEvidence-based medicineRehabilitation |
| spellingShingle | S. Porter I.J. Torres W. Panenka Z. Rajwani D. Fawcett A. Hyder N. Virji-Babul Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury Heliyon Neurology Evidence-based medicine Rehabilitation |
| title | Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury |
| title_full | Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury |
| title_fullStr | Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury |
| title_full_unstemmed | Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury |
| title_short | Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury |
| title_sort | changes in brain behavior relationships following a 3 month pilot cognitive intervention program for adults with traumatic brain injury |
| topic | Neurology Evidence-based medicine Rehabilitation |
| url | http://www.sciencedirect.com/science/article/pii/S240584401731592X |
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