Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer
Alterations in the switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complex are enriched in advanced thyroid cancer. Integrase interactor 1 (INI1), encoded by the <i>SMARCB1</i> gene on the long arm of chromosome 22, is one of the core subunits of the SWI/SNF com...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/5/280 |
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| author | Kung-Chen Ho Jie-Jen Lee Chi-Hsin Lin Ching-Hsiang Leung Shih-Ping Cheng |
| author_facet | Kung-Chen Ho Jie-Jen Lee Chi-Hsin Lin Ching-Hsiang Leung Shih-Ping Cheng |
| author_sort | Kung-Chen Ho |
| collection | DOAJ |
| description | Alterations in the switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complex are enriched in advanced thyroid cancer. Integrase interactor 1 (INI1), encoded by the <i>SMARCB1</i> gene on the long arm of chromosome 22, is one of the core subunits of the SWI/SNF complex. INI1 immunohistochemistry is frequently used for the diagnosis of malignant rhabdoid neoplasms. In the present study, we found normal and benign thyroid tissues generally had diffusely intense nuclear immunostaining. Loss of INI1 immunohistochemical expression was observed in 8% of papillary thyroid cancer and 30% of follicular thyroid cancer. Furthermore, loss of INI1 expression was associated with extrathyroidal extension (<i>p</i> < 0.001) and lymph node metastasis (<i>p</i> = 0.038). Analysis of The Cancer Genome Atlas database revealed that SMARCB1 underexpression was associated with the follicular variant subtype and aneuploidy in papillary thyroid cancer. We speculate that SMARCB1 is an important effector in addition to NF2 and CHEK2 inactivation among thyroid cancers with chromosome 22q loss. |
| first_indexed | 2024-03-10T20:01:52Z |
| format | Article |
| id | doaj.art-d27d6dfdd7a3416b8d72716af90e8c20 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:01:52Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-d27d6dfdd7a3416b8d72716af90e8c202023-11-19T23:32:02ZengMDPI AGDiagnostics2075-44182020-05-0110528010.3390/diagnostics10050280Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid CancerKung-Chen Ho0Jie-Jen Lee1Chi-Hsin Lin2Ching-Hsiang Leung3Shih-Ping Cheng4Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei 104215, TaiwanDepartment of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei 104215, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei 104215, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, MacKay Memorial Hospital and Mackay Medical College, Taipei 104215, TaiwanDepartment of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei 104215, TaiwanAlterations in the switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complex are enriched in advanced thyroid cancer. Integrase interactor 1 (INI1), encoded by the <i>SMARCB1</i> gene on the long arm of chromosome 22, is one of the core subunits of the SWI/SNF complex. INI1 immunohistochemistry is frequently used for the diagnosis of malignant rhabdoid neoplasms. In the present study, we found normal and benign thyroid tissues generally had diffusely intense nuclear immunostaining. Loss of INI1 immunohistochemical expression was observed in 8% of papillary thyroid cancer and 30% of follicular thyroid cancer. Furthermore, loss of INI1 expression was associated with extrathyroidal extension (<i>p</i> < 0.001) and lymph node metastasis (<i>p</i> = 0.038). Analysis of The Cancer Genome Atlas database revealed that SMARCB1 underexpression was associated with the follicular variant subtype and aneuploidy in papillary thyroid cancer. We speculate that SMARCB1 is an important effector in addition to NF2 and CHEK2 inactivation among thyroid cancers with chromosome 22q loss.https://www.mdpi.com/2075-4418/10/5/280SMARCB1integrase interactor 1thyroid carcinomaaneuploidy |
| spellingShingle | Kung-Chen Ho Jie-Jen Lee Chi-Hsin Lin Ching-Hsiang Leung Shih-Ping Cheng Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer Diagnostics SMARCB1 integrase interactor 1 thyroid carcinoma aneuploidy |
| title | Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer |
| title_full | Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer |
| title_fullStr | Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer |
| title_full_unstemmed | Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer |
| title_short | Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer |
| title_sort | loss of integrase interactor 1 ini1 expression in a subset of differentiated thyroid cancer |
| topic | SMARCB1 integrase interactor 1 thyroid carcinoma aneuploidy |
| url | https://www.mdpi.com/2075-4418/10/5/280 |
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