Comprehensive behavioral phenotyping of calpastatin-knockout mice
<p>Abstract</p> <p>Background</p> <p>Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpast...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-09-01
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| Series: | Molecular Brain |
| Online Access: | http://www.molecularbrain.com/content/1/1/7 |
| _version_ | 1811314295063969792 |
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| author | Nakajima Ryuichi Takao Keizo Huang Shu-Ming Takano Jiro Iwata Nobuhisa Miyakawa Tsuyoshi Saido Takaomi C |
| author_facet | Nakajima Ryuichi Takao Keizo Huang Shu-Ming Takano Jiro Iwata Nobuhisa Miyakawa Tsuyoshi Saido Takaomi C |
| author_sort | Nakajima Ryuichi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery.</p> <p>Results</p> <p>Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but we observed no significant change in hippocampus-dependent memory function.</p> <p>Conclusion</p> <p>These results suggest that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.</p> |
| first_indexed | 2024-04-13T11:09:20Z |
| format | Article |
| id | doaj.art-d27f10b8d7784134af168cdde135a3b1 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-04-13T11:09:20Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-d27f10b8d7784134af168cdde135a3b12022-12-22T02:49:10ZengBMCMolecular Brain1756-66062008-09-0111710.1186/1756-6606-1-7Comprehensive behavioral phenotyping of calpastatin-knockout miceNakajima RyuichiTakao KeizoHuang Shu-MingTakano JiroIwata NobuhisaMiyakawa TsuyoshiSaido Takaomi C<p>Abstract</p> <p>Background</p> <p>Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery.</p> <p>Results</p> <p>Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but we observed no significant change in hippocampus-dependent memory function.</p> <p>Conclusion</p> <p>These results suggest that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.</p>http://www.molecularbrain.com/content/1/1/7 |
| spellingShingle | Nakajima Ryuichi Takao Keizo Huang Shu-Ming Takano Jiro Iwata Nobuhisa Miyakawa Tsuyoshi Saido Takaomi C Comprehensive behavioral phenotyping of calpastatin-knockout mice Molecular Brain |
| title | Comprehensive behavioral phenotyping of calpastatin-knockout mice |
| title_full | Comprehensive behavioral phenotyping of calpastatin-knockout mice |
| title_fullStr | Comprehensive behavioral phenotyping of calpastatin-knockout mice |
| title_full_unstemmed | Comprehensive behavioral phenotyping of calpastatin-knockout mice |
| title_short | Comprehensive behavioral phenotyping of calpastatin-knockout mice |
| title_sort | comprehensive behavioral phenotyping of calpastatin knockout mice |
| url | http://www.molecularbrain.com/content/1/1/7 |
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