Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different?
Abstract Background Staphylococci and streptococci are the most frequent pathogens isolated from prosthetic joint infections (PJIs). The aim of this study was to analyze the outcome of streptococcal and methicillin-susceptible Staphylococcus aureus (MSSA) PJIs. Methods All monomicrobial streptococca...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07532-x |
| _version_ | 1828725704878981120 |
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| author | Yousra Kherabi Valérie Zeller Younes Kerroumi Vanina Meyssonnier Beate Heym Olivier Lidove Simon Marmor |
| author_facet | Yousra Kherabi Valérie Zeller Younes Kerroumi Vanina Meyssonnier Beate Heym Olivier Lidove Simon Marmor |
| author_sort | Yousra Kherabi |
| collection | DOAJ |
| description | Abstract Background Staphylococci and streptococci are the most frequent pathogens isolated from prosthetic joint infections (PJIs). The aim of this study was to analyze the outcome of streptococcal and methicillin-susceptible Staphylococcus aureus (MSSA) PJIs. Methods All monomicrobial streptococcal and MSSA PJIs managed in a French Referral Center (2010–2017) were sampled from the prospective PJIs cohort study. The primary outcome of interest was the cumulative reinfection-free survival at a 2-year follow-up. Results Two hundred and nine patients with 91 streptococcal and 132 staphylococcal infections were analyzed. Patients with streptococcal PJI were older, and infection was more frequently hematogenous. Reinfection-free survival rates at 2-years after all treatment strategies were higher for patients with streptococcal PJI (91% vs 81%; P = .012), but differed according to the strategy. After exchange arthroplasty, no outcome differences were observed (89% vs 93%; P = .878); after debridement, antibiotics and implant retention (DAIR), the reinfection-free survival rate was higher for patients with streptococcal PJI (87% vs 60%; P = .062). For patients managed with prolonged suppressive antibiotic therapy (SAT) alone, those with streptococcal PJIs had a 100% infection-free survival (100% vs 31%; P < .0001). Conclusions Reinfection-free survival after DAIR and SAT was better for patients with streptococcal than those with MSSA PJIs. No difference was observed after prosthesis exchange. |
| first_indexed | 2024-04-12T13:31:29Z |
| format | Article |
| id | doaj.art-d27fc4965a7a46fab3beb317b7f2dd53 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T13:31:29Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-d27fc4965a7a46fab3beb317b7f2dd532022-12-22T03:31:10ZengBMCBMC Infectious Diseases1471-23342022-06-0122111010.1186/s12879-022-07532-xStreptococcal and Staphylococcus aureus prosthetic joint infections: are they really different?Yousra Kherabi0Valérie Zeller1Younes Kerroumi2Vanina Meyssonnier3Beate Heym4Olivier Lidove5Simon Marmor6Centre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-SimonCentre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-SimonCentre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-SimonCentre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-SimonCentre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-SimonService de Médecine Interne et Infectiologie, Groupe Hospitalier Diaconesses-Croix Saint-SimonCentre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-SimonAbstract Background Staphylococci and streptococci are the most frequent pathogens isolated from prosthetic joint infections (PJIs). The aim of this study was to analyze the outcome of streptococcal and methicillin-susceptible Staphylococcus aureus (MSSA) PJIs. Methods All monomicrobial streptococcal and MSSA PJIs managed in a French Referral Center (2010–2017) were sampled from the prospective PJIs cohort study. The primary outcome of interest was the cumulative reinfection-free survival at a 2-year follow-up. Results Two hundred and nine patients with 91 streptococcal and 132 staphylococcal infections were analyzed. Patients with streptococcal PJI were older, and infection was more frequently hematogenous. Reinfection-free survival rates at 2-years after all treatment strategies were higher for patients with streptococcal PJI (91% vs 81%; P = .012), but differed according to the strategy. After exchange arthroplasty, no outcome differences were observed (89% vs 93%; P = .878); after debridement, antibiotics and implant retention (DAIR), the reinfection-free survival rate was higher for patients with streptococcal PJI (87% vs 60%; P = .062). For patients managed with prolonged suppressive antibiotic therapy (SAT) alone, those with streptococcal PJIs had a 100% infection-free survival (100% vs 31%; P < .0001). Conclusions Reinfection-free survival after DAIR and SAT was better for patients with streptococcal than those with MSSA PJIs. No difference was observed after prosthesis exchange.https://doi.org/10.1186/s12879-022-07532-xProsthetic joint infectionMethicillin-susceptible Staphylococcus aureusStreptococcus spp |
| spellingShingle | Yousra Kherabi Valérie Zeller Younes Kerroumi Vanina Meyssonnier Beate Heym Olivier Lidove Simon Marmor Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different? BMC Infectious Diseases Prosthetic joint infection Methicillin-susceptible Staphylococcus aureus Streptococcus spp |
| title | Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different? |
| title_full | Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different? |
| title_fullStr | Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different? |
| title_full_unstemmed | Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different? |
| title_short | Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different? |
| title_sort | streptococcal and staphylococcus aureus prosthetic joint infections are they really different |
| topic | Prosthetic joint infection Methicillin-susceptible Staphylococcus aureus Streptococcus spp |
| url | https://doi.org/10.1186/s12879-022-07532-x |
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