Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter
Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2018-03-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500612&lng=en&tlng=en |
| _version_ | 1828451035832647680 |
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| author | T.P. Chao E.F. Sperandio T.L.V.P. Ostolin V.R. Almeida M. Romiti A.R.T. Gagliardi R.L. Arantes V.Z. Dourado |
| author_facet | T.P. Chao E.F. Sperandio T.L.V.P. Ostolin V.R. Almeida M. Romiti A.R.T. Gagliardi R.L. Arantes V.Z. Dourado |
| author_sort | T.P. Chao |
| collection | DOAJ |
| description | Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of ΔVT/ΔlnV̇E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the ΔVT/ΔlnV̇E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers. |
| first_indexed | 2024-12-10T23:31:11Z |
| format | Article |
| id | doaj.art-d2807d80b71b41039c0a2a814a17b7dd |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-10T23:31:11Z |
| publishDate | 2018-03-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-d2807d80b71b41039c0a2a814a17b7dd2022-12-22T01:29:24ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2018-03-0151510.1590/1414-431x20186486S0100-879X2018000500612Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matterT.P. ChaoE.F. SperandioT.L.V.P. OstolinV.R. AlmeidaM. RomitiA.R.T. GagliardiR.L. ArantesV.Z. DouradoSpirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure. After collection of self-reported socioeconomic status, educational level, and cardiovascular risk data, participants underwent spirometry, CPET, body composition assessment (bioelectrical impedance), and triaxial accelerometry (for level of physical activity in daily life). CPET was performed using a ramp protocol on a treadmill. Metabolic, cardiovascular, ventilatory, and submaximal relationships were measured. We compared 52 exposed to 83 non-exposed workers. Multiple linear regressions were developed using spirometry and CPET variables as outcomes and OEPM as the main predictor, and adjusted by the main covariates. Our results showed that OEPM was associated with significant reductions in peak minute ventilation, peak tidal volume, and breathing reserve index. Exposed participants presented shallower slope of ΔVT/ΔlnV̇E (breathing pattern), i.e., increased tachypneic breathing pattern. The OEPM explained 7.4% of the ΔVT/ΔlnV̇E variability. We found no significant influence of spirometric indices after multiple linear regressions. We conclude that CPET might be a more sensitive feature of assessing early pulmonary impairment related to OEPM. Our cross-sectional results suggested that CPET is a promising tool for the screening of asymptomatic male workers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500612&lng=en&tlng=enOccupational exposure to particulate matterCardiopulmonary exercise testingDetectionSpirometryVentilatory impairment |
| spellingShingle | T.P. Chao E.F. Sperandio T.L.V.P. Ostolin V.R. Almeida M. Romiti A.R.T. Gagliardi R.L. Arantes V.Z. Dourado Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter Brazilian Journal of Medical and Biological Research Occupational exposure to particulate matter Cardiopulmonary exercise testing Detection Spirometry Ventilatory impairment |
| title | Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
| title_full | Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
| title_fullStr | Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
| title_full_unstemmed | Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
| title_short | Use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
| title_sort | use of cardiopulmonary exercise testing to assess early ventilatory changes related to occupational particulate matter |
| topic | Occupational exposure to particulate matter Cardiopulmonary exercise testing Detection Spirometry Ventilatory impairment |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500612&lng=en&tlng=en |
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