Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study
Background: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show negative effects on tumor formation, necessitating c...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1185850/full |
| _version_ | 1797794661116411904 |
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| author | Jiahao Zhu Jie Lian Xin Wang Ren Wang Xiangyi Pang Benjie Xu Xing Wang Chenyang Li Shengjun Ji Haibo Lu |
| author_facet | Jiahao Zhu Jie Lian Xin Wang Ren Wang Xiangyi Pang Benjie Xu Xing Wang Chenyang Li Shengjun Ji Haibo Lu |
| author_sort | Jiahao Zhu |
| collection | DOAJ |
| description | Background: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show negative effects on tumor formation, necessitating characterization of the causal associations between antioxidants and cancer risk.Methods: In this study, Mendelian randomization (MR) analysis, primarily inverse-variance weighted MR, was used to assess the causal effect of six endogenous and five exogenous diet-derived antioxidants on the risk of six cancers. MR-Egger intercept test and Cochran’s Q statistic were utilized to assess pleiotropy and heterogeneity, respectively.Results: For endogenous antioxidants, a bidirectional two-sample MR analysis was conducted. Our findings suggested that serum albumin has a negative causal association with the risk of prostate cancer [odds ratio (OR) = 0.78, 95% confidence interval (CI): 0.68–0.91, p = 0.001]. The risks of the six cancers showed no significant associations with endogenous antioxidants in the converse MR analysis. For exogenous antioxidants, the unidirectional two-sample MR analysis exhibited a nominal relationship between the serum retinol level and non-small-cell lung cancer risk (OR = 0.29, 95% CI: 0.11–0.76, p = 0.011).Conclusions: Thus, our study revealed the protective effects of genetic susceptibility to high circulating albumin levels on prostate cancer, providing potential targeted interventions for prostate cancer prevention. |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T03:06:10Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-d280dcbcfce3474d80c0e2a2ad78284c2023-06-27T05:20:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-06-011410.3389/fphar.2023.11858501185850Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization studyJiahao Zhu0Jie Lian1Xin Wang2Ren Wang3Xiangyi Pang4Benjie Xu5Xing Wang6Chenyang Li7Shengjun Ji8Haibo Lu9Harbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaThe Affiliated Suzhou Hospital of Nanjing Medical University, Department of Radiotherapy and Oncology, Suzhou, ChinaHarbin Medical University Cancer Hospital, Department of Outpatient Chemotherapy, Harbin, ChinaBackground: Although oxidative stress is known to contribute to cancer, and endogenous and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative stress-induced DNA damage, antioxidants have also been reported to show negative effects on tumor formation, necessitating characterization of the causal associations between antioxidants and cancer risk.Methods: In this study, Mendelian randomization (MR) analysis, primarily inverse-variance weighted MR, was used to assess the causal effect of six endogenous and five exogenous diet-derived antioxidants on the risk of six cancers. MR-Egger intercept test and Cochran’s Q statistic were utilized to assess pleiotropy and heterogeneity, respectively.Results: For endogenous antioxidants, a bidirectional two-sample MR analysis was conducted. Our findings suggested that serum albumin has a negative causal association with the risk of prostate cancer [odds ratio (OR) = 0.78, 95% confidence interval (CI): 0.68–0.91, p = 0.001]. The risks of the six cancers showed no significant associations with endogenous antioxidants in the converse MR analysis. For exogenous antioxidants, the unidirectional two-sample MR analysis exhibited a nominal relationship between the serum retinol level and non-small-cell lung cancer risk (OR = 0.29, 95% CI: 0.11–0.76, p = 0.011).Conclusions: Thus, our study revealed the protective effects of genetic susceptibility to high circulating albumin levels on prostate cancer, providing potential targeted interventions for prostate cancer prevention.https://www.frontiersin.org/articles/10.3389/fphar.2023.1185850/fulloxidative stressendogenous antioxidantexogenous antioxidantcancer preventionMendelian randomization study |
| spellingShingle | Jiahao Zhu Jie Lian Xin Wang Ren Wang Xiangyi Pang Benjie Xu Xing Wang Chenyang Li Shengjun Ji Haibo Lu Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study Frontiers in Pharmacology oxidative stress endogenous antioxidant exogenous antioxidant cancer prevention Mendelian randomization study |
| title | Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study |
| title_full | Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study |
| title_fullStr | Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study |
| title_full_unstemmed | Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study |
| title_short | Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study |
| title_sort | role of endogenous and exogenous antioxidants in risk of six cancers evidence from the mendelian randomization study |
| topic | oxidative stress endogenous antioxidant exogenous antioxidant cancer prevention Mendelian randomization study |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1185850/full |
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