Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience

Objective Ki-67 is associated with breast cancer subtypes, but the optimal cutoff point of Ki-67 has not been established in our center. We evaluated the cutoff point of Ki-67 in breast cancer and analyzed the associations among Ki-67, clinicopathological features, and prognosis. Methods The clinico...

Full description

Bibliographic Details
Main Authors: Wang Li, Ning Lu, Caiping Chen, Xiang Lu
Format: Article
Language:English
Published: SAGE Publishing 2023-08-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/03000605231195468
_version_ 1797692966934937600
author Wang Li
Ning Lu
Caiping Chen
Xiang Lu
author_facet Wang Li
Ning Lu
Caiping Chen
Xiang Lu
author_sort Wang Li
collection DOAJ
description Objective Ki-67 is associated with breast cancer subtypes, but the optimal cutoff point of Ki-67 has not been established in our center. We evaluated the cutoff point of Ki-67 in breast cancer and analyzed the associations among Ki-67, clinicopathological features, and prognosis. Methods The clinicopathological data and prognostic information of patients with breast cancer treated in our center were retrospectively collected, and the optimal cutoff point of Ki-67 was determined by univariate and multivariate survival risk analyses. The cutoff point was used to group the patients, and the differences in the clinicopathological features and prognosis were analyzed between the two groups. Results In total, 609 patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative primary breast cancer were enrolled. The mean Ki-67 value was 22.3% ± 15.4%, the median was 20%, and a cutoff point of 30% was an independent factor influencing recurrence-free survival. When 30% was used as the cutoff point, patients with a Ki-67 value of ≤30% had a better prognosis and lower tumor malignancy. Conclusion The optimal cutoff point of Ki-67 in breast cancer in our center is 30%.
first_indexed 2024-03-12T02:35:14Z
format Article
id doaj.art-d282d9f8785e43a8a395bbdca7393507
institution Directory Open Access Journal
issn 1473-2300
language English
last_indexed 2024-03-12T02:35:14Z
publishDate 2023-08-01
publisher SAGE Publishing
record_format Article
series Journal of International Medical Research
spelling doaj.art-d282d9f8785e43a8a395bbdca73935072023-09-04T20:33:24ZengSAGE PublishingJournal of International Medical Research1473-23002023-08-015110.1177/03000605231195468Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experienceWang LiNing LuCaiping ChenXiang LuObjective Ki-67 is associated with breast cancer subtypes, but the optimal cutoff point of Ki-67 has not been established in our center. We evaluated the cutoff point of Ki-67 in breast cancer and analyzed the associations among Ki-67, clinicopathological features, and prognosis. Methods The clinicopathological data and prognostic information of patients with breast cancer treated in our center were retrospectively collected, and the optimal cutoff point of Ki-67 was determined by univariate and multivariate survival risk analyses. The cutoff point was used to group the patients, and the differences in the clinicopathological features and prognosis were analyzed between the two groups. Results In total, 609 patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative primary breast cancer were enrolled. The mean Ki-67 value was 22.3% ± 15.4%, the median was 20%, and a cutoff point of 30% was an independent factor influencing recurrence-free survival. When 30% was used as the cutoff point, patients with a Ki-67 value of ≤30% had a better prognosis and lower tumor malignancy. Conclusion The optimal cutoff point of Ki-67 in breast cancer in our center is 30%.https://doi.org/10.1177/03000605231195468
spellingShingle Wang Li
Ning Lu
Caiping Chen
Xiang Lu
Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
Journal of International Medical Research
title Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
title_full Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
title_fullStr Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
title_full_unstemmed Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
title_short Identifying the optimal cutoff point of Ki-67 in breast cancer: a single-center experience
title_sort identifying the optimal cutoff point of ki 67 in breast cancer a single center experience
url https://doi.org/10.1177/03000605231195468
work_keys_str_mv AT wangli identifyingtheoptimalcutoffpointofki67inbreastcancerasinglecenterexperience
AT ninglu identifyingtheoptimalcutoffpointofki67inbreastcancerasinglecenterexperience
AT caipingchen identifyingtheoptimalcutoffpointofki67inbreastcancerasinglecenterexperience
AT xianglu identifyingtheoptimalcutoffpointofki67inbreastcancerasinglecenterexperience