Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy
Abstract Background Theranostic nanoparticles (NPs) have achieved rapid development owing to their capacity for personalized multimodal diagnostic imaging and antitumor therapy. However, the efficient delivery and bulk accumulation of NPs in tumors are still the decisive factors in improving therape...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00875-8 |
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| author | Qiaolin Wei Jian He Shuaifei Wang Shiyuan Hua Yuchen Qi Fangyuan Li Daishun Ling Min Zhou |
| author_facet | Qiaolin Wei Jian He Shuaifei Wang Shiyuan Hua Yuchen Qi Fangyuan Li Daishun Ling Min Zhou |
| author_sort | Qiaolin Wei |
| collection | DOAJ |
| description | Abstract Background Theranostic nanoparticles (NPs) have achieved rapid development owing to their capacity for personalized multimodal diagnostic imaging and antitumor therapy. However, the efficient delivery and bulk accumulation of NPs in tumors are still the decisive factors in improving therapeutic effect. It is urgent to seek other methods to alters tumor microenvironment (like vascular permeability and density) for enhancing the efficiency of nanoparticles delivery and accumulation at the tumor site. Methods Herein, we developed a Raman-tagged hollow gold nanoparticle (termed as HAuNP@DTTC) with surface-enhanced Raman scattering (SERS) property, which could be accumulated efficiently in tumor site with the pre-irradiation of low-dose (3 Gy) X-ray and then exerted highly antitumor effect in breast cancer model. Results The tumor growth inhibition (TGI) of HAuNP@DTTC-induced photothermal therapy (PTT) was increased from 60% for PTT only to 97%, and the lethal distant metastasis of 4T1 breast cancer (such as lung and liver) were effectively inhibited under the X-ray-assisted PTT treatment. Moreover, with the strong absorbance induced by localized surface plasmon resonance in near-infrared (NIR) region, the signals of Raman/photoacoustic (PA) imaging in tumor was also significantly enhanced after the administration of HAuNP@DTTC, indicating it could be used as the Raman/PA imaging and photothermal agent simultaneously under 808 nm laser irradiation. Conclusions Our studied of the as-prepared HAuNP@DTTC integrated the Raman/PA imaging and PTT functions into the single platform, and showed the good prospects for clinical applications especially with the low-dose X-ray irradiation as an adjuvant, which will be a productive strategy for enhancing drug delivery and accumulation in tumor theranostics. Graphic Abstract |
| first_indexed | 2024-04-11T18:10:10Z |
| format | Article |
| id | doaj.art-d2837e9796c24d1393a2330d4ce5f155 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T18:10:10Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-d2837e9796c24d1393a2330d4ce5f1552022-12-22T04:10:11ZengBMCJournal of Nanobiotechnology1477-31552021-05-0119111710.1186/s12951-021-00875-8Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapyQiaolin Wei0Jian He1Shuaifei Wang2Shiyuan Hua3Yuchen Qi4Fangyuan Li5Daishun Ling6Min Zhou7Eye Center, The Second Affiliated Hospital, Zhejiang University School of MedicineInstitute of Translational Medicine, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Translational Medicine, Zhejiang UniversityInstitute of Translational Medicine, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityInstitute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang UniversityEye Center, The Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Background Theranostic nanoparticles (NPs) have achieved rapid development owing to their capacity for personalized multimodal diagnostic imaging and antitumor therapy. However, the efficient delivery and bulk accumulation of NPs in tumors are still the decisive factors in improving therapeutic effect. It is urgent to seek other methods to alters tumor microenvironment (like vascular permeability and density) for enhancing the efficiency of nanoparticles delivery and accumulation at the tumor site. Methods Herein, we developed a Raman-tagged hollow gold nanoparticle (termed as HAuNP@DTTC) with surface-enhanced Raman scattering (SERS) property, which could be accumulated efficiently in tumor site with the pre-irradiation of low-dose (3 Gy) X-ray and then exerted highly antitumor effect in breast cancer model. Results The tumor growth inhibition (TGI) of HAuNP@DTTC-induced photothermal therapy (PTT) was increased from 60% for PTT only to 97%, and the lethal distant metastasis of 4T1 breast cancer (such as lung and liver) were effectively inhibited under the X-ray-assisted PTT treatment. Moreover, with the strong absorbance induced by localized surface plasmon resonance in near-infrared (NIR) region, the signals of Raman/photoacoustic (PA) imaging in tumor was also significantly enhanced after the administration of HAuNP@DTTC, indicating it could be used as the Raman/PA imaging and photothermal agent simultaneously under 808 nm laser irradiation. Conclusions Our studied of the as-prepared HAuNP@DTTC integrated the Raman/PA imaging and PTT functions into the single platform, and showed the good prospects for clinical applications especially with the low-dose X-ray irradiation as an adjuvant, which will be a productive strategy for enhancing drug delivery and accumulation in tumor theranostics. Graphic Abstracthttps://doi.org/10.1186/s12951-021-00875-8Gold NanoparticlesX-ray IrradiationRaman ImagingPhotoacoustic Imaging Photothermal Therapy |
| spellingShingle | Qiaolin Wei Jian He Shuaifei Wang Shiyuan Hua Yuchen Qi Fangyuan Li Daishun Ling Min Zhou Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy Journal of Nanobiotechnology Gold Nanoparticles X-ray Irradiation Raman Imaging Photoacoustic Imaging Photothermal Therapy |
| title | Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy |
| title_full | Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy |
| title_fullStr | Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy |
| title_full_unstemmed | Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy |
| title_short | Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy |
| title_sort | low dose x ray enhanced tumor accumulation of theranostic nanoparticles for high performance bimodal imaging guided photothermal therapy |
| topic | Gold Nanoparticles X-ray Irradiation Raman Imaging Photoacoustic Imaging Photothermal Therapy |
| url | https://doi.org/10.1186/s12951-021-00875-8 |
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