miR-29c-5p knockdown reduces inflammation and blood–brain barrier disruption by upregulating LRP6

miR-29c-5p knockdown reduces inflammation and blood–brain barrier disruption by upregulating LRP6

Blood–brain barrier participates in the pathological process of ischemic stroke. MicroRNA-29c-5p was highly expressed in clinical samples from patients with ischemic stroke. In this study, oxygen-glucose deprivation (OGD) treatment of astrocytes enhanced the permeability of brain microvascular endot...

Full description

Bibliographic Details
Main Authors:	Dai Qijun, Sun Jian, Dai Tianyi, Xu Qin, Ding Yueqin
Format:	Article
Language:	English
Published:	De Gruyter 2022-02-01
Series:	Open Medicine
Subjects:	ischemic stroke blood–brain barrier brain microvascular endothelial cells astrocytes mirna
Online Access:	https://doi.org/10.1515/med-2022-0438

Similar Items

Stroke-induced damage on the blood–brain barrier
by: Song Xue, et al.
Published: (2023-09-01)

Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice
by: Shotaro Michinaga, et al.
Published: (2022-11-01)

Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer’s disease
by: Qian Yue, et al.
Published: (2023-01-01)

In vitro model of the blood-brain barrier established by co-culture of primary sheep cerebral microvascular endothelial and astrocyte cells
by: Jingjing REN, et al.
Published: (2018-03-01)

Zika virus E protein modulates functions of human brain microvascular endothelial cells and astrocytes: implications on blood-brain barrier properties
by: Guneet Kaur, et al.
Published: (2023-07-01)

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier
by: Tianqi Xu, et al.
Published: (2024-01-01)

The CCL2 synthesis inhibitor <it>bindarit</it> targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis
by: Ge Shujun, et al.
Published: (2012-07-01)

In vitro model of the blood-brain barrier established by co-culture of primary cerebral microvascular endothelial and astrocyte cells
by: Yan Wang, et al.
Published: (2015-01-01)

Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke
by: Jinghuan Wang, et al.
Published: (2022-03-01)

circ_2858 Helps Blood-Brain Barrier Disruption by Increasing VEGFA via Sponging miR-93-5p during Escherichia coli Meningitis
by: Ruicheng Yang, et al.
Published: (2020-12-01)

Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models
by: Tracy D. Chung, et al.
Published: (2022-05-01)

Exosomal Mir-3613-3p derived from oxygen–glucose deprivation-treated brain microvascular endothelial cell promotes microglial M1 polarization
by: Mengqi Zhang, et al.
Published: (2023-03-01)

Pneumococcal Encounter With the Blood–Brain Barrier Endothelium
by: Anjali Anil, et al.
Published: (2020-11-01)

Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration
by: M.M. Tenreiro, et al.
Published: (2016-07-01)

A novel PGAM5 inhibitor LFHP-1c protects blood–brain barrier integrity in ischemic stroke
by: Chenglong Gao, et al.
Published: (2021-07-01)

Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery
by: Ke Wang, et al.
Published: (2023-07-01)

Loss of Endothelial Barrier Function in the Inflammatory Setting: Indication for a Cytokine-Mediated Post-Transcriptional Mechanism by Virtue of Upregulation of miRNAs miR-29a-3p, miR-29b-3p, and miR-155-5p
by: Daniel Maucher, et al.
Published: (2021-10-01)

Establishment and comparison of in vitro blood-brain barrier cell models
by: SU Yu-wen, XIU Jian-bo, XU Qi
Published: (2022-05-01)

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study
by: Inês ePalmela, et al.
Published: (2015-03-01)

Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes
by: Daisuke Watanabe, et al.
Published: (2021-09-01)

Blood–Brain Barrier Integrity Damage in Bacterial Meningitis: The Underlying Link, Mechanisms, and Therapeutic Targets
by: Ruicheng Yang, et al.
Published: (2023-02-01)

The Effects of Propofol on a Human in vitro Blood-Brain Barrier Model
by: Jason M. Hughes, et al.
Published: (2022-05-01)

Role of NADPH Oxidases in Blood–Brain Barrier Disruption and Ischemic Stroke
by: Marina S. Hernandes, et al.
Published: (2022-09-01)

The Cellular Dysfunction of the Brain–Blood Barrier from Endothelial Cells to Astrocytes: The Pathway towards Neurotransmitter Impairment in Schizophrenia
by: Stefano Stanca, et al.
Published: (2024-01-01)

RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
by: Rubin Hao, et al.
Published: (2020-01-01)

TGF-β and SHH Regulate Pluripotent Stem Cell Differentiation into Brain Microvascular Endothelial Cells in Generating an In Vitro Blood–Brain Barrier Model
by: Na Geum Lee, et al.
Published: (2023-09-01)

Isolation and Cultivation of Porcine Endothelial Cells, Pericytes and Astrocytes to Develop an In Vitro Blood–Brain Barrier Model for Drug Permeation Testing
by: Verena Ledwig, et al.
Published: (2023-06-01)

Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier
by: Gabriella Schiera, et al.
Published: (2024-01-01)

Breaking and building the wall: the biology of the blood-brain barrier in health and disease
by: Annika Keller
Published: (2013-11-01)

Reactive astrocytes associated with prion disease impair the blood brain barrier
by: Rajesh Kushwaha, et al.
Published: (2023-09-01)

The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model
by: Moriah E. Katt, et al.
Published: (2019-07-01)

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury
by: Zaib A. Shaheryar, et al.
Published: (2021-10-01)

Brain Infection by Hepatitis E Virus Probably via Damage of the Blood-Brain Barrier Due to Alterations of Tight Junction Proteins
by: Jijing Tian, et al.
Published: (2019-03-01)

Inhibiting YAP in Endothelial Cells From Entering the Nucleus Attenuates Blood-Brain Barrier Damage During Ischemia-Reperfusion Injury
by: Shuaishuai Gong, et al.
Published: (2021-11-01)

Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity
by: Hiromasa Aoki, et al.
Published: (2020-03-01)

The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier
by: Layla Burn, et al.
Published: (2021-09-01)

Astrocyte Involvement in Blood–Brain Barrier Function: A Critical Update Highlighting Novel, Complex, Neurovascular Interactions
by: Doina Ramona Manu, et al.
Published: (2023-12-01)

Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy
by: Raleigh M. Linville, et al.
Published: (2021-12-01)

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke
by: Yilong Shan, et al.
Published: (2019-11-01)

The Role of Astrocytes and Blood–Brain Barrier Disruption in Alzheimer’s Disease
by: João Victor R. Cruz, et al.
Published: (2023-08-01)