Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina.
Hepatitis B virus (HBV) is a globally distributed human pathogen that leads to both self-limited and chronic infections. At least eight genotypes (A-H) with distinct geographical allocations and phylodynamic behaviors have been described. They differ substantially in many virological and probably so...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4951016?pdf=render |
| _version_ | 1818480888994856960 |
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| author | María Belén Rodrigo Laura Noelia Mojsiejczuk Carolina Torres Ina Sevic María Mora González López Ledesma Paula Soledad Perez María Belén Bouzas Omar Galdame Sebastián Marciano Hugo Fainboim Diego Martín Flichman Rodolfo Héctor Campos |
| author_facet | María Belén Rodrigo Laura Noelia Mojsiejczuk Carolina Torres Ina Sevic María Mora González López Ledesma Paula Soledad Perez María Belén Bouzas Omar Galdame Sebastián Marciano Hugo Fainboim Diego Martín Flichman Rodolfo Héctor Campos |
| author_sort | María Belén Rodrigo |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) is a globally distributed human pathogen that leads to both self-limited and chronic infections. At least eight genotypes (A-H) with distinct geographical allocations and phylodynamic behaviors have been described. They differ substantially in many virological and probably some clinical parameters. The aim of this study was to analyze full-length HBV genome sequences from individuals with symptomatic acute HBV infections using phylogenetic and coalescent methods. The phylogenetic analysis resulted in the following subgenotype distribution: F1b (52.7%), A2 (18.2%), F4 (18.2%) and A1, B2, D3 and F2a 1.8% each. These results contrast with those previously reported from chronic infections, where subgenotypes F1b, F4, A2 and genotype D were evenly distributed. This differential distribution might be related to recent internal migrations and/or intrinsic biological features of each viral genotype that could impact on the probability of transmission. The coalescence analysis showed that after a diversification process started in the 80s, the current sequences of subgenotype F1b were grouped in at least four highly supported lineages, whereas subgenotype F4 revealed a more limited diversification pattern with most lineages without offspring in the present. In addition, the genetic characterization of the studied sequences showed that only two of them presented mutations of clinical relevance at S codifyng region and none at the polymerase catalytic domains. Finally, since the acute infections could be an expression of the genotypes currently being transmitted to new hosts, the predominance of subgenotype F1b might have epidemiological, as well as, clinical relevance due to its potential adverse disease outcome among the chronic cases. |
| first_indexed | 2024-12-10T11:28:11Z |
| format | Article |
| id | doaj.art-d28727c3687a478ea174eaf48e219db3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T11:28:11Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d28727c3687a478ea174eaf48e219db32022-12-22T01:50:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01117e015950910.1371/journal.pone.0159509Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina.María Belén RodrigoLaura Noelia MojsiejczukCarolina TorresIna SevicMaría Mora González López LedesmaPaula Soledad PerezMaría Belén BouzasOmar GaldameSebastián MarcianoHugo FainboimDiego Martín FlichmanRodolfo Héctor CamposHepatitis B virus (HBV) is a globally distributed human pathogen that leads to both self-limited and chronic infections. At least eight genotypes (A-H) with distinct geographical allocations and phylodynamic behaviors have been described. They differ substantially in many virological and probably some clinical parameters. The aim of this study was to analyze full-length HBV genome sequences from individuals with symptomatic acute HBV infections using phylogenetic and coalescent methods. The phylogenetic analysis resulted in the following subgenotype distribution: F1b (52.7%), A2 (18.2%), F4 (18.2%) and A1, B2, D3 and F2a 1.8% each. These results contrast with those previously reported from chronic infections, where subgenotypes F1b, F4, A2 and genotype D were evenly distributed. This differential distribution might be related to recent internal migrations and/or intrinsic biological features of each viral genotype that could impact on the probability of transmission. The coalescence analysis showed that after a diversification process started in the 80s, the current sequences of subgenotype F1b were grouped in at least four highly supported lineages, whereas subgenotype F4 revealed a more limited diversification pattern with most lineages without offspring in the present. In addition, the genetic characterization of the studied sequences showed that only two of them presented mutations of clinical relevance at S codifyng region and none at the polymerase catalytic domains. Finally, since the acute infections could be an expression of the genotypes currently being transmitted to new hosts, the predominance of subgenotype F1b might have epidemiological, as well as, clinical relevance due to its potential adverse disease outcome among the chronic cases.http://europepmc.org/articles/PMC4951016?pdf=render |
| spellingShingle | María Belén Rodrigo Laura Noelia Mojsiejczuk Carolina Torres Ina Sevic María Mora González López Ledesma Paula Soledad Perez María Belén Bouzas Omar Galdame Sebastián Marciano Hugo Fainboim Diego Martín Flichman Rodolfo Héctor Campos Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina. PLoS ONE |
| title | Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina. |
| title_full | Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina. |
| title_fullStr | Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina. |
| title_full_unstemmed | Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina. |
| title_short | Analysis of the Molecular Evolution of Hepatitis B Virus Genotypes in Symptomatic Acute Infections in Argentina. |
| title_sort | analysis of the molecular evolution of hepatitis b virus genotypes in symptomatic acute infections in argentina |
| url | http://europepmc.org/articles/PMC4951016?pdf=render |
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