Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we dis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/1/61 |
| _version_ | 1797410251003133952 |
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| author | Alberto Cagigi Karin Loré |
| author_facet | Alberto Cagigi Karin Loré |
| author_sort | Alberto Cagigi |
| collection | DOAJ |
| description | In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans. |
| first_indexed | 2024-03-09T04:26:13Z |
| format | Article |
| id | doaj.art-d2874a8a2ddc45488398b348382e8578 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T04:26:13Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d2874a8a2ddc45488398b348382e85782023-12-03T13:40:10ZengMDPI AGVaccines2076-393X2021-01-01916110.3390/vaccines9010061Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and HumansAlberto Cagigi0Karin Loré1Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, SwedenDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, SwedenIn this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.https://www.mdpi.com/2076-393X/9/1/61mRNA vaccinedendritic cellprotein translationtype I interferonTh1 polarizationantibody response |
| spellingShingle | Alberto Cagigi Karin Loré Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans Vaccines mRNA vaccine dendritic cell protein translation type I interferon Th1 polarization antibody response |
| title | Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans |
| title_full | Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans |
| title_fullStr | Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans |
| title_full_unstemmed | Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans |
| title_short | Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans |
| title_sort | immune responses induced by mrna vaccination in mice monkeys and humans |
| topic | mRNA vaccine dendritic cell protein translation type I interferon Th1 polarization antibody response |
| url | https://www.mdpi.com/2076-393X/9/1/61 |
| work_keys_str_mv | AT albertocagigi immuneresponsesinducedbymrnavaccinationinmicemonkeysandhumans AT karinlore immuneresponsesinducedbymrnavaccinationinmicemonkeysandhumans |